Morbid obesity is a chronic multifunctional disease characterized by an accumulation of fat.
Epidemiological studies have shown that obesity is associated with cardiovascular and …

Endothelium plays a crucial role in modulating vascular function and structure, mainly by
production of nitric oxide which protects the vasculature against the development of …

The endothelium plays a crucial role in modulating vascular function and structure. In
healthy conditions, nitric oxide produced by endothelial cells exerts not only vasodilating …

Obesity is a metabolic disorder of increasing prevalence worldwide and a risk factor for the
development of insulin resistance (IR), metabolic syndrome and type 2 diabetes. Obesity is …

Obesity dramatically increases the risk of development of cardiovascular and metabolic
diseases. Endothelial dysfunction induced by obesity is an important risk factor that impairs …

Endothelium modulates vascular function and structure, mainly by production of nitric oxide
which protects the vasculature against the development of atherosclerosis and thrombosis …

Obesity is an ongoing worldwide epidemic. Besides being a medical condition in itself,
obesity dramatically increases the risk of development of metabolic and cardiovascular …

Chronic inflammatory state in obesity causes dysregulation of the endocrine and paracrine
actions of adipocyte-derived factors, which disrupt vascular homeostasis and contribute to …

Abstract Purpose of Review To examine the state of the art on the pathogenesis of
endothelial dysfunction in the microcirculation of patients with obesity, focusing on the …

Obesity, insulin resistance, and endothelial dysfunction closely coexist throughout the
natural history of type 2 diabetes. They all can be identified not only in people with type 2 …