Gut bacteria-driven homovanillic acid alleviates depression by modulating synaptic integrity
The gut-brain axis is implicated in depression development, yet its underlying mechanism
remains unclear. We observed depleted gut bacterial species, including Bifidobacterium …
remains unclear. We observed depleted gut bacterial species, including Bifidobacterium …
Gut microbiota changes require vagus nerve integrity to promote depressive-like behaviors in mice
E Siopi, M Galerne, M Rivagorda, S Saha… - Molecular …, 2023 - nature.com
Chronic stress constitutes a major risk factor for depression that can disrupt various aspects
of homeostasis, including the gut microbiome (GM). We have recently shown that GM …
of homeostasis, including the gut microbiome (GM). We have recently shown that GM …
[HTML][HTML] Brain–gut–microbiota axis in depression: A historical overview and future directions
Depression is the most common mental disorder and a leading cause of disability
worldwide. Despite abundant research, the precise mechanisms underlying the …
worldwide. Despite abundant research, the precise mechanisms underlying the …
[HTML][HTML] Towards a psychobiotic therapy for depression: Bifidobacterium breve CCFM1025 reverses chronic stress-induced depressive symptoms and gut microbial …
Background Accumulating evidence points to an association between gut microbial
abnormalities and depression disorder. The microbiota-gut-brain axis is an emerging target …
abnormalities and depression disorder. The microbiota-gut-brain axis is an emerging target …
Oral treatment with Lactobacillus reuteri attenuates depressive-like behaviors and serotonin metabolism alterations induced by chronic social defeat stress
R Xie, P Jiang, LI Lin, J Jiang, B Yu, J Rao, H Liu… - Journal of Psychiatric …, 2020 - Elsevier
Background Alterations in bidirectional gut–brain interactions are believed to be involved in
the pathogenesis of neuropsychiatric diseases. Considering the putative connections …
the pathogenesis of neuropsychiatric diseases. Considering the putative connections …
Microbiota alterations in proline metabolism impact depression
J Mayneris-Perxachs, A Castells-Nobau… - Cell metabolism, 2022 - cell.com
The microbiota-gut-brain axis has emerged as a novel target in depression, a disorder with
low treatment efficacy. However, the field is dominated by underpowered studies focusing …
low treatment efficacy. However, the field is dominated by underpowered studies focusing …
The role of inflammation and the gut microbiome in depression and anxiety
JM Peirce, K Alviña - Journal of neuroscience research, 2019 - Wiley Online Library
The study of the gut microbiome has increasingly revealed an important role in modulating
brain function and mental health. In this review, we underscore specific pathways and …
brain function and mental health. In this review, we underscore specific pathways and …
Role of microbiota and tryptophan metabolites in the remote effect of intestinal inflammation on brain and depression
B Waclawiková, S El Aidy - Pharmaceuticals, 2018 - mdpi.com
The human gastrointestinal tract is inhabited by trillions of commensal bacteria collectively
known as the gut microbiota. Our recognition of the significance of the complex interaction …
known as the gut microbiota. Our recognition of the significance of the complex interaction …
Bacteroides species differentially modulate depression-like behavior via gut-brain metabolic signaling
Y Zhang, Q Fan, Y Hou, X Zhang, Z Yin, X Cai… - Brain, behavior, and …, 2022 - Elsevier
Gut microbiome disturbances have been widely implicated in major depressive disorder
(MDD), although the identity of causal microbial species and the underlying mechanisms are …
(MDD), although the identity of causal microbial species and the underlying mechanisms are …
How microbes affect depression: underlying mechanisms via the Gut–brain axis and the modulating role of probiotics
K Suda, K Matsuda - International journal of molecular sciences, 2022 - mdpi.com
Accumulating evidence suggests that the gut microbiome influences the brain functions and
psychological state of its host via the gut–brain axis, and gut dysbiosis has been linked to …
psychological state of its host via the gut–brain axis, and gut dysbiosis has been linked to …