Formation, function, and pathology of RNP granules

N Ripin, R Parker - Cell, 2023 - cell.com
Ribonucleoprotein (RNP) granules are diverse membrane-less organelles that form through
multivalent RNA-RNA, RNA-protein, and protein-protein interactions between RNPs. RNP …

Mechanisms and regulation of RNA condensation in RNP granule formation

D Tauber, G Tauber, R Parker - Trends in biochemical sciences, 2020 - cell.com
Ribonucleoprotein (RNP) granules are RNA–protein assemblies that are involved in
multiple aspects of RNA metabolism and are linked to memory, development, and disease …

[HTML][HTML] Granulostasis: protein quality control of RNP granules

S Alberti, D Mateju, L Mediani, S Carra - Frontiers in molecular …, 2017 - frontiersin.org
Ribonucleoprotein (RNP) granules transport, store, or degrade messenger RNAs, thereby
indirectly regulating protein synthesis. Normally, RNP granules are highly dynamic …

[HTML][HTML] Emerging roles for intermolecular RNA-RNA interactions in RNP assemblies

B Van Treeck, R Parker - Cell, 2018 - cell.com
Eukaryotic cells contain large assemblies of RNA and protein, referred to as
ribonucleoprotein (RNP) granules, which include cytoplasmic P-bodies, stress granules, and …

Are stress granules the RNA analogs of misfolded protein aggregates?

N Ripin, R Parker - Rna, 2022 - rnajournal.cshlp.org
Ribonucleoprotein granules are ubiquitous features of eukaryotic cells. Several
observations argue that the formation of at least some RNP granules can be considered …

RNA granules: functional compartments or incidental condensates?

A Putnam, L Thomas, G Seydoux - Genes & development, 2023 - genesdev.cshlp.org
RNA granules are mesoscale assemblies that form in the absence of limiting membranes.
RNA granules contain factors for RNA biogenesis and turnover and are often assumed to …

RNA is required for the integrity of multiple nuclear and cytoplasmic membrane‐less RNP granules

CJ Decker, JM Burke, PK Mulvaney, R Parker - The EMBO journal, 2022 - embopress.org
Numerous membrane‐less organelles, composed of a combination of RNA and proteins,
are observed in the nucleus and cytoplasm of eukaryotic cells. These RNP granules include …

Multiple modes of protein–protein interactions promote RNP granule assembly

T Mittag, R Parker - Journal of molecular biology, 2018 - Elsevier
Eukaryotic cells are known to contain a wide variety of RNA–protein assemblies, collectively
referred to as RNP granules. RNP granules form from a combination of RNA–RNA, protein …

RNP granule formation: lessons from P-bodies and stress granules

GA Corbet, R Parker - Cold Spring Harbor symposia on …, 2019 - symposium.cshlp.org
It is now clear that cells form a wide collection of large RNA–protein assemblies, referred to
as RNP granules. RNP granules exist in bacterial cells and can be found in both the cytosol …

[HTML][HTML] Friend or foe—Post-translational modifications as regulators of phase separation and RNP granule dynamics

M Hofweber, D Dormann - Journal of Biological Chemistry, 2019 - ASBMB
Ribonucleoprotein (RNP) granules are membrane-less organelles consisting of RNA-
binding proteins (RBPs) and RNA. RNA granules form through liquid–liquid phase …