Tuberculosis kills over 1· 7 million people worldwide every year and nearly 40% of patients
with active tuberculosis remain undiagnosed because of the poor sensitivity of the current …

SETTING: The Chest Clinic and the JICA (Japan International Cooperation Agency)
Molecular Laboratories, University Teaching Hospital, Lusaka, Zambia, and the Department …

Various polymerase chain reaction (PCR) assays have been devised for the rapid
identification of mycobacteria in clinical specimens. To assess the value of such assays in …

SETTING: A tertiary care and research institution in Italy. BACKGROUND: Small DNA
fragments from cells dying throughout the body have been detected in urine (transrenal DNA …

Background There is a need for rapid diagnosis of pulmonary tuberculosis. We have
previously used a PCR to detect circulating Mycobacterium tuberculosis DNA in blood …

Sputum examination for rapid diagnosis of pulmonary tuberculosis is not always satisfactory.
We examined peripheral blood with the polymerase chain reaction (PCR). Blood samples …

Purpose Molecular diagnostics of patients with MTB tuberculosis from urine samples.
Methods We developed a new molecular assay based on the detection of M. tuberculosis …

Nucleic acid amplification to detect Mycobacterium tuberculosis in clinical specimens is
increasingly used as a laboratory tool for the diagnosis of tuberculosis. However, the …

Tuberculosis (TB) diagnosis among sputum-scarce patients is time consuming. Thus, a
nonsputum diagnostic alternative is urgently needed. The Mycobacterium tuberculosis …

Both the urine LAM and PCR for mycobacterial DNA are being evaluated in different
geographical settings. Urine LAM currently offers little utility for the diagnosis of tuberculosis …