Kinetic characterization of an efficient cocaine hydrolase against toxic metabolites of cocaine
In the presence of alcohol, cocaine metabolism produces a number of metabolites, including
three toxic ones (cocaethylene, norcocaine, and norcocaethylene) which are all more toxic …
three toxic ones (cocaethylene, norcocaine, and norcocaethylene) which are all more toxic …
Catalytic activities of cocaine hydrolases against the most toxic cocaine metabolite norcocaethylene
A majority of cocaine users also consume alcohol. The concurrent use of cocaine and
alcohol produces the pharmacologically active metabolites cocaethylene and …
alcohol produces the pharmacologically active metabolites cocaethylene and …
Catalytic activities of a highly efficient cocaine hydrolase for hydrolysis of biologically active cocaine metabolites norcocaine and benzoylecgonine
Cocaine is a widely abused, hepatotoxic drug without an FDA-approved pharmacotherapy
specific for cocaine addiction or overdose. It is recognized as a promising therapeutic …
specific for cocaine addiction or overdose. It is recognized as a promising therapeutic …
Reaction pathway and free energy profile for cocaine hydrolase-catalyzed hydrolysis of (−)-cocaine
The reaction pathway of (−)-cocaine hydrolysis catalyzed by our recently discovered, most
efficient cocaine hydrolase, which is the A199S/F227A/S287G/A328W/Y332G mutant of …
efficient cocaine hydrolase, which is the A199S/F227A/S287G/A328W/Y332G mutant of …
Toward cocaine esterase therapeutics
CJ Rogers, JM Mee, GF Kaufmann… - Journal of the …, 2005 - ACS Publications
Cocaine is among the most reinforcing of all drugs of abuse, yet no effective
pharmacotherapy is available. Herein, we report the development and characterization of …
pharmacotherapy is available. Herein, we report the development and characterization of …
Reaction mechanism for cocaine esterase-catalyzed hydrolyses of (+)-and (−)-cocaine: unexpected common rate-determining step
First-principles quantum mechanical/molecular mechanical free energy calculations have
been performed to examine the catalytic mechanism for cocaine esterase (CocE)-catalyzed …
been performed to examine the catalytic mechanism for cocaine esterase (CocE)-catalyzed …
Catalytic reaction mechanism for drug metabolism in human carboxylesterase-1: cocaine hydrolysis pathway
Carboxylesterase-1 (CE-1) is a crucial enzyme responsible for metabolism/activation/
inactivation of xenobiotics (therapeutic agents, prodrugs, abused drugs, and …
inactivation of xenobiotics (therapeutic agents, prodrugs, abused drugs, and …
Human carboxylesterase 2 in cocaine metabolism
Increased hydrolysis of cocaine to nontoxic compounds is a promising way to prevent
cocaine-induced toxicity. However, the short half-life of cocaine in the blood and the rapid …
cocaine-induced toxicity. However, the short half-life of cocaine in the blood and the rapid …
Clinical potential of an enzyme-based novel therapy for cocaine overdose
It is a grand challenge to develop a truly effective medication for treatment of cocaine
overdose. The current available, practical emergence treatment for cocaine overdose …
overdose. The current available, practical emergence treatment for cocaine overdose …
Fundamental reaction mechanism and free energy profile for (−)-cocaine hydrolysis catalyzed by cocaine esterase
The fundamental reaction mechanism of cocaine esterase (CocE)-catalyzed hydrolysis of (−)-
cocaine and the corresponding free energy profile have been studied by performing …
cocaine and the corresponding free energy profile have been studied by performing …