Antiretroviral therapy can effectively block HIV-1 replication and prevent or reverse
immunodeficiency in HIV-1-infected individuals. However, viral replication resumes within …

Highly active antiretroviral therapy (HAART) suppresses HIV-1 replication, transforming the
outlook for infected patients. However, reservoirs of replication-competent forms of the virus …

The presence of persistent, latent HIV reservoirs in CD4+ T cells obstructs current efforts to
cure infection. The so-called kick-and-kill paradigm proposes to purge these reservoirs by …

The discovery of a stable latent reservoir for HIV‐1 in resting memory CD4+ T cells provides
a mechanism for lifelong persistence of HIV‐1. The long‐lived latently infected cells persist …

Current antiretroviral therapy effectively suppresses but does not eradicate HIV-1 infection.
During therapy patients maintain a persistent low-level viremia requiring lifelong adherence …

Antiretroviral therapy (ART) is able to suppress HIV-1 replication indefinitely in individuals
who have access to these medications, are able to tolerate these drugs, and are motivated …

Thirty-five years after the identification of HIV-1 as the causative agent of AIDS, we are still in
search of vaccines and treatments to eradicate this devastating infectious disease. Progress …

HIV-1 infection persists even after years of antiretroviral therapy (ART). Although ART can
halt viral replication and thereby reduce viremia to clinically undetectable levels, proviral …

The success of combination antiretroviral therapy for HIV-1 infection has generated interest
in mechanisms by which the virus can persist in the body despite the presence of drugs that …

Combination antiretroviral therapy (ART) can suppress plasma HIV to undetectable levels,
allowing HIV-infected individuals who are treated early a nearly normal life span. Despite …