In this review, we will discuss the safety of repeated treatments with ketamine for patients
with treatment-resistant depression (TRD), a condition in which patients with major …

Background Ketamine is reported to have rapid antidepressant effects; however, there is
limited understanding of the time-course of ketamine effects beyond a single infusion. A …

Background Several studies indicate that ketamine has rapid antidepressant effects in
patients with treatment-resistant depression (TRD). The extent to which repeated doses of …

BACKGROUND: Acute administration of subanesthestic doses of intravenous ketamine
have been shown to elicit a rapid antidepressant response in patients with treatment …

BACKGROUND: A single subanesthetic (intravenous) IV dose of ketamine might have rapid
but transient antidepressant effects in patients with treatment-resistant depression (TRD) …

Introduction Ketamine treatment is capable of significant and rapid symptom improvement in
adults with treatment-resistant depression (TRD). A limitation of ketamine treatment in TRD …

Objective: Subanesthetic ketamine doses have been shown to have rapid yet transient
antidepressant effects in patients with treatment-resistant depression, which may be …

Background Due to unmet clinical needs for efficient drugs with a rapid onset of
antidepressant effects, we aimed to evaluate the efficacy of single-dose ketamine in different …

Objectives We examined the feasibility of a high-dose, 96-h infusion of ketamine in treatment-
resistant depression. Methods Ten participants were randomised to receive a 96-h ketamine …

Objectives. Research studies have reported impressive antidepressant effects with ketamine
but significant knowledge gaps remain over the best method of administering ketamine, and …