Is there a placental microbiota? A critical review and re-analysis of published placental microbiota datasets
The existence of a placental microbiota is debated. The human placenta has historically
been considered sterile and microbial colonization was associated with adverse pregnancy …
been considered sterile and microbial colonization was associated with adverse pregnancy …
Comparison of placenta samples with contamination controls does not provide evidence for a distinct placenta microbiota
AP Lauder, AM Roche, S Sherrill-Mix, A Bailey… - Microbiome, 2016 - Springer
Background Recent studies have suggested that bacteria associated with the placenta—a
“placental microbiome”—may be important in reproductive health and disease. However, a …
“placental microbiome”—may be important in reproductive health and disease. However, a …
Microbial communities in placentas from term normal pregnancy exhibit spatially variable profiles
LA Parnell, CM Briggs, B Cao, O Delannoy-Bruno… - Scientific reports, 2017 - nature.com
The placenta is the principal organ nurturing the fetus during pregnancy and was
traditionally considered to be sterile. Recent work has suggested that the placenta harbours …
traditionally considered to be sterile. Recent work has suggested that the placenta harbours …
Lack of detection of a human placenta microbiome in samples from preterm and term deliveries
Background Historically, the human womb has been thought to be sterile in healthy
pregnancies, but this idea has been challenged by recent studies using DNA sequence …
pregnancies, but this idea has been challenged by recent studies using DNA sequence …
Does the human placenta delivered at term have a microbiota? Results of cultivation, quantitative real-time PCR, 16S rRNA gene sequencing, and metagenomics
Background The human placenta has been traditionally viewed as sterile, and microbial
invasion of this organ has been associated with adverse pregnancy outcomes. Yet, recent …
invasion of this organ has been associated with adverse pregnancy outcomes. Yet, recent …
Deep microbial analysis of multiple placentas shows no evidence for a placental microbiome
AA Kuperman, A Zimmerman… - … Journal of Obstetrics …, 2020 - Wiley Online Library
Objectives To resolve the controversy regarding the presence of a microbiota in the
placenta. Design Classical and molecular microbiological study. Setting All samples were …
placenta. Design Classical and molecular microbiological study. Setting All samples were …
Elimination of “kitome” and “splashome” contamination results in lack of detection of a unique placental microbiome
IN Olomu, LC Pena-Cortes, RA Long, A Vyas… - BMC microbiology, 2020 - Springer
Background A placental microbiome, which may be altered in gestational diabetes mellitus
(GDM), has been described. However, publications raising doubts about the existence of a …
(GDM), has been described. However, publications raising doubts about the existence of a …
The placenta harbors a unique microbiome
Humans and their microbiomes have coevolved as a physiologic community composed of
distinct body site niches with metabolic and antigenic diversity. The placental microbiome …
distinct body site niches with metabolic and antigenic diversity. The placental microbiome …
Comment on “the placenta harbors a unique microbiome”
HJ Kliman - Science translational medicine, 2014 - science.org
Comment on “The placenta harbors a unique microbiome” | Science Translational Medicine
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Evidence for contamination as the origin for bacteria found in human placenta rather than a microbiota
Until recently the in utero environment of pregnant women was considered sterile. Recent
high-sensitivity molecular techniques and high-throughput sequencing lead to some …
high-sensitivity molecular techniques and high-throughput sequencing lead to some …