Fungal aflatoxins reduce respiratory mucosal ciliary function

RJ Lee, AD Workman, RM Carey, B Chen, PL Rosen… - Scientific Reports, 2016 - nature.com
Aflatoxins are mycotoxins secreted by Aspergillus flavus, which can colonize the respiratory
tract and cause fungal rhinosinusitis or bronchopulmonary aspergillosis. A. flavus is the …

Verruculogen associated with Aspergillus fumigatus hyphae and conidia modifies the electrophysiological properties of human nasal epithelial cells

K Khoufache, O Puel, N Loiseau, M Delaforge… - BMC microbiology, 2007 - Springer
Abstract Background The role of Aspergillus fumigatus mycotoxins in the colonization of the
respiratory tract by conidia has not been studied extensively, even though patients at risk …

Elimination of Aspergillus fumigatus conidia from the airways of mice with allergic airway inflammation

MA Shevchenko, EL Bolkhovitina, EA Servuli… - Respiratory …, 2013 - Springer
Background Aspergillus fumigatus conidia can exacerbate asthma symptoms. Phagocytosis
of conidia is a principal component of the host antifungal defense. We investigated whether …

The Impact of Aspergillus fumigatus Viability and Sensitization to Its Allergens on the Murine Allergic Asthma Phenotype

S Pandey, SA Hoselton… - BioMed Research …, 2013 - Wiley Online Library
Aspergillus fumigatus is a ubiquitously present respiratory pathogen. The outcome of a
pulmonary disease may vary significantly with fungal viability and host immune status. Our …

Aspergillus fumigatus cell wall promotes apical airway epithelial recruitment of human neutrophils

MB Feldman, RA Dutko, MA Wood, RA Ward… - Infection and …, 2020 - Am Soc Microbiol
Aspergillus fumigatus is a ubiquitous fungal pathogen capable of causing multiple
pulmonary diseases, including invasive aspergillosis, chronic necrotizing aspergillosis …

Aspergillus fumigatus Inhibits Pseudomonas aeruginosa in Co-culture: Implications of a Mutually Antagonistic Relationship on Virulence and Inflammation in the CF …

E Reece, S Doyle, P Greally, J Renwick… - Frontiers in …, 2018 - frontiersin.org
Many cystic fibrosis (CF) airway infections are considered to be polymicrobial and microbe–
microbe interactions may play an important role in disease pathology. Pseudomonas …

Characterization of Lung Inflammatory Response to Aspergillus fumigatus Spores

A Bouyssi, T Déméautis, A Trecourt, M Delles… - Journal of Fungi, 2023 - mdpi.com
The airway exposure to Aspergillus fumigatus spores (AFsp) is associated with an
inflammatory response, potentially leading to allergic and/or chronic pulmonary …

Aspergillus fumigatus viability drives allergic responses to inhaled conidia

AP Nayak, TL Croston, AR Lemons… - Annals of Allergy …, 2018 - Elsevier
Background Aspergillus fumigatus–induced allergic airway disease has been shown to
involve conidial germination in vivo, but the immunological mechanisms remain …

Exposure to Aspergillus fumigatus spores induces chemokine expression in mouse macrophages

L Pylkkänen, H Gullstén, ML Majuri, U Andersson… - Toxicology, 2004 - Elsevier
Inhalation of fungal spores may cause inflammation and respiratory diseases, such as
bronchitis, allergic alveolitis, and asthma. Alveolar macrophages provide the first line of …

Aspergillus‐Associated Airway Disease, Inflammation, and the Innate Immune Response

SH Chotirmall, M Al-Alawi, B Mirkovic… - BioMed research …, 2013 - Wiley Online Library
Aspergillus moulds exist ubiquitously as spores that are inhaled in large numbers daily.
Whilst most are removed by anatomical barriers, disease may occur in certain …