Despite recent discoveries of genetic variants associated with autoimmunity and infection,
genetic control of the human immune system during homeostasis is poorly understood. We …

The chronic autoimmune diseases include multiple complex genetic disorders. Recently,
genome-wide association studies (GWAS) have identified a large number of major loci, with …

Autoimmune diseases display a high degree of comorbidity within individuals and families,
suggesting shared risk factors. Over the past 15 years, genome-wide association studies …

Genome-wide strategies have driven the discovery of more than 300 susceptibility loci for
autoimmune diseases. However, for almost all loci, understanding of the mechanisms …

Autoimmune diseases affect up to approximately 10% of the population. While rare
Mendelian autoimmunity syndromes can result from monogenic mutations disrupting …

Recent genetic studies in multiple autoimmune and inflammatory diseases have identified
hundreds of genomic loci harboring risk variants. These variants are shared between …

Genome-wide association studies are transformative in revealing the polygenetic basis of
common diseases, with autoimmune diseases leading the charge. Although the field is just …

In the past few years, our extensive knowledge of the mammalian immune system and our
increasing ability to understand the genetic causes of complex human disease have opened …

The complex network of specialized cells and molecules in the immune system has evolved
to defend against pathogens, but inadvertent immune system attacks on" self" result in …

The development of most autoimmune diseases includes a strong heritable component. This
genetic contribution to disease ranges from simple Mendelian inheritance of causative …