Innovations in gene discovery and the analysis of gene expression are facilitating the
identification of a growing number of antigens that could potentially be targeted for …

Immunotherapies are emerging as highly promising approaches for the treatment of cancer.
In these approaches, a variety of materials are used to boost immunity against malignant …

Since the establishment of methods to isolate genes encoding cytotoxic T lymphocyte
defined tumor antigens, several antigens have been identified and characterized for …

Antigen-specific tumor immunotherapy remains an attractive strategy for the treatment of
malignancies. In this review we will discuss why, despite the identification of large numbers …

The genetic modification of CD8+ T cells using anti-tumor T-cell receptors (TCR) or chimeric
antigen receptors is a promising approach for the adoptive cell therapy of patients with …

In an effort to broaden the applicability of adoptive cellular immunotherapy toward
nonmelanoma cancers, we have designed chimeric antibody/T-cell receptor genes …

Although T cells genetically modified with chimeric antigen receptors became the first
immune effector product to obtain FDA approval, T-cell products that recognize their …

Adoptively transferred tumor-specific cells can mediate tumor regression in cancers
refractory to conventional therapy. Autologous polyclonal tumor-specific cytotoxic T cells …

Adoptive T cell therapy is a promising treatment strategy for patients with different types of
cancer. The methods used for generation of high numbers of tumor specific T cells usually …

Adoptive T cell therapy involves the ex vivo selection and expansion of effector cells for the
treatment of patients with cancer. In this review, the advantages and limitations of using …