The intestinal mucosal barrier controlling the resident microbiome is dependent on a
protective mucus layer generated by goblet cells, impairment of which is a hallmark of the …

Epithelial barrier defects are implicated in the pathogenesis of inflammatory bowel disease
(IBD); however, the role of microbiome dysbiosis and the cytokine networks orchestrating …

Mice deficient in the IL-10 pathway are the most widely used models of intestinal
immunopathology. IL-17A is strongly implicated in gut disease in mice and humans, but …

Elevated levels of interleukin-18 (IL-18) are found in many chronic inflammatory disorders,
including inflammatory bowel disease (IBD), and polymorphisms in the IL18R1–IL18RAP …

Cytokines maintain intestinal health, but precise intercellular communication networks
remain poorly understood. Macrophages are immune sentinels of the intestinal tissue and …

Breakdown of the epithelial barrier because of toxins or other insults leads to severe colitis.
Interleukin-10 (IL-10) is a critical regulator of this, yet its cellular targets and mechanisms of …

Cytokines secreted at sites of inflammation impact the onset, progression, and resolution of
inflammation. In this article, we investigated potential proresolving mechanisms of IFN-γ in …

In the IL-17 family of cytokines, much is known about the sources and functions of IL-17, IL-
17F, and IL-25 in the host defense against infection and in inflammatory diseases; however …

Abstract Interleukin 10 (IL10) is a key anti-inflammatory cytokine that can inhibit
proinflammatory responses of both innate and adaptive immune cells. An association …

Abstract Aims Ulcerative colitis and Crohn's disease, collectively known as inflammatory
bowel disease (IBD), are chronic inflammatory disorders of the intestine for which key …