OBJECTIVE: Streamlining the initiation of allopurinol could result in a cost benefit for a
common medical problem and obviate the perception that no treatment is required once …

Background Traditionally, allopurinol is not initiated during an acute gout attack to avoid
prolonging the painful arthritis. The 2012 American College of Rheumatology Guidelines for …

Objective. To study the frequency of normal serum urate (SU) levels during acute gout in the
largest studies of acute gout treatment to date. Methods. Data collected from 2 randomized …

Objectives Allopurinol is the most widely prescribed serum uric acid-lowering therapy (ULT)
in gout. To achieve serum uric acid (sUA) concentrations associated with clinical benefit …

Background: The desired serum urate level (SUA) for prevention of gout attacks is widely
recommended to be in the subsaturating range,< 6.0 mg/dL. Objectives: The objectives of …

Abstract Objectives European League against Rheumatism (EULAR) gout management
guidelines recommend achieving a target urate level< 6.0 mg/dL (< 357 µmol/L). Allopurinol …

OBJECTIVE: The use of colchicine to prevent acute gout flares during initiation of allopurinol
therapy is widely practiced despite lack of proven benefit. We investigated if colchicine …

Objective To determine the efficacy and safety of increasing the allopurinol dose above the
proposed creatinine clearance–based dose in patients with gout. Methods Patients with gout …

Objectives To determine the efficacy and safety of allopurinol dose escalation using a treat-
to-target serum urate (SU) approach. Methods A randomised, controlled, parallel-group …

Objective: Although gout has recognized prevention and treatment options, some patients
have recurrent unplanned hospital admissions with gout flares. The aim of this study was to …