A nanoparticulate dual scavenger for targeted therapy of inflammatory bowel disease

C Shi, J Dawulieti, F Shi, C Yang, Q Qin, T Shi… - Science …, 2022 - science.org
A therapeutic strategy that targets multiple proinflammatory factors in inflammatory bowel
disease (IBD) with minimal systemic side effects would be attractive. Here, we develop a …

Polycatechol-derived mesoporous polydopamine nanoparticles for combined ROS scavenging and gene interference therapy in inflammatory bowel disease

L Wang, Z Wang, Y Pan, S Chen, X Fan… - … Applied Materials & …, 2022 - ACS Publications
Benefiting from the evolution of nanotechnology, the combination therapy by gene
interference and reactive oxygen species (ROS) scavenging are expected, which holds …

Treatment of severe sepsis with nanoparticulate cell-free DNA scavengers

J Dawulieti, M Sun, Y Zhao, D Shao, H Yan, YH Lao… - Science …, 2020 - science.org
Severe sepsis represents a common, expensive, and deadly health care issue with limited
therapeutic options. Gaining insights into the inflammatory dysregulation that causes sepsis …

Nanoparticulate drug delivery systems targeting inflammation for treatment of inflammatory bowel disease

S Zhang, R Langer, G Traverso - Nano Today, 2017 - Elsevier
Inflammatory bowel disease (IBD) is a chronic, idiopathic inflammatory set of conditions that
can affect the entire gastrointestinal (GI) tract and is associated with an increased risk of …

Nanoparticles for oral delivery: targeted therapy for inflammatory bowel disease

D Li, M Yang, H Xu, M Zhu, Y Zhang, C Tian… - Journal of Materials …, 2022 - pubs.rsc.org
As a group of chronic and idiopathic gastrointestinal (GI) disorders, inflammatory bowel
disease (IBD) is characterized by recurrent intestinal mucosal inflammation. Oral …

A drug-free nanozyme for mitigating oxidative stress and inflammatory bowel disease

F Zeng, Y Shi, C Wu, J Liang, Q Zhong, K Briley… - Journal of …, 2022 - Springer
Inflammatory bowel disease (IBD) is an incurable disease of the gastrointestinal tract with a
lack of effective therapeutic strategies. The proinflammatory microenvironment plays a …

A superoxide dismutase/catalase mimetic nanomedicine for targeted therapy of inflammatory bowel disease

Q Zhang, H Tao, Y Lin, Y Hu, H An, D Zhang, S Feng… - Biomaterials, 2016 - Elsevier
Oxidative stress, resulting from excessive generation of reactive oxygen species (ROS),
plays a pivotal role in the initiation and progression of inflammatory bowel disease (IBD). To …

Nanoparticle-based oral drug delivery systems targeting the colon for treatment of ulcerative colitis

M Zhang, D Merlin - Inflammatory bowel diseases, 2018 - academic.oup.com
Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis
(UC), is characterized by chronic relapsing inflammation of the gastrointestinal tract. Delivery …

Orally administrated inflamed colon-targeted nanotherapeutics for inflammatory bowel disease treatment by oxidative stress level modulation in colitis

DK Min, YE Kim, MK Kim, SW Choi, N Park, J Kim - ACS nano, 2023 - ACS Publications
Inflammatory bowel disease (IBD) is characterized by an inappropriate and persistent
inflammatory immune response and is often accompanied by excessive reactive oxygen …

[HTML][HTML] Reactive oxygen species-responsive nanocarrier ameliorates murine colitis by intervening colonic innate and adaptive immune responses

X Yan, L Meng, X Zhang, Z Deng, B Gao, Y Zhang… - Molecular Therapy, 2023 - cell.com
Ulcerative colitis (UC) is a chronic or relapsing inflammatory disease with limited therapeutic
outcomes. Pterostilbene (PSB) is a polyphenol-based anti-oxidant that has received …