Oral administration of oxytocin, like intranasal administration, decreases top-down social attention

Q Zhuang, X Zheng, S Yao, W Zhao… - International Journal …, 2022 - academic.oup.com
Background The neuropeptide oxytocin (OXT) modulates social cognition by increasing
attention to social cues and may have therapeutic potential for impaired social attention in …

Oro-mucosal administration of oxytocin using medicated lollipops alters social attention, similar to intranasal and lingual routes: Implications for therapeutic use

D Xu, Q Li, Q Zhuang, Y Zhang, S Yao… - Frontiers in …, 2022 - frontiersin.org
A key functional effect of intranasal administration of the neuropeptide oxytocin is on top-
down control of social attention. However, an oro-mucosal administration route may be …

Oxytocin reduces top-down control of attention by increasing bottom-up attention allocation to social but not non-social stimuli–a randomized controlled trial

X Xu, J Li, Z Chen, KM Kendrick, B Becker - Psychoneuroendocrinology, 2019 - Elsevier
The neuropeptide oxytocin (OXT) may facilitate attention to social stimuli by influencing early
stage bottom-up processing although findings in relation to different emotional expressions …

Intranasal oxytocin selectively attenuates rhesus monkeys' attention to negative facial expressions

LA Parr, M Modi, E Siebert, LJ Young - Psychoneuroendocrinology, 2013 - Elsevier
Intranasal oxytocin (IN-OT) modulates social perception and cognition in humans and could
be an effective pharmacotherapy for treating social impairments associated with …

Aerosolized oxytocin increases cerebrospinal fluid oxytocin in rhesus macaques

ME Modi, F Connor-Stroud, R Landgraf… - …, 2014 - Elsevier
Intranasal (IN) administration is a widely used method for examining the effect of oxytocin
(OT) on social behavior and cognition in healthy subjects and psychiatric populations. IN-OT …

Dose-dependent social-cognitive effects of intranasal oxytocin delivered with novel Breath Powered device in adults with autism spectrum disorder: a randomized …

DS Quintana, LT Westlye, S Hope, T Naerland… - Translational …, 2017 - nature.com
The neuropeptide oxytocin has shown promise as a treatment for symptoms of autism
spectrum disorders (ASD). However, clinical research progress has been hampered by a …

Intranasal vasopressin like oxytocin increases social attention by influencing top-down control, but additionally enhances bottom-up control

Q Zhuang, X Zheng, B Becker, W Lei, X Xu… - …, 2021 - Elsevier
The respective roles of the neuropeptides arginine vasopressin (AVP) and oxytocin (OXT) in
modulating social cognition and for therapeutic intervention in autism spectrum disorder …

Mitigation of sociocommunicational deficits of autism through oxytocin-induced recovery of medial prefrontal activity: a randomized trial

T Watanabe, O Abe, H Kuwabara, N Yahata… - JAMA …, 2014 - jamanetwork.com
Importance Sociocommunicational deficits make it difficult for individuals with autism
spectrum disorders (ASD) to understand communication content with conflicting verbal and …

Oxytocin effects on the human brain: findings, questions, and future directions

O Weisman, R Feldman - Biological Psychiatry, 2013 - biologicalpsychiatryjournal.com
Since the discovery that intranasal administration of neuro-peptides can have a direct impact
on the human brain, extant research has been devoted to understanding the effects of …

Do blood plasma levels of oxytocin moderate the effect of nasally administered oxytocin on social orienting in high-functioning male adults with autism spectrum …

M Althaus, Y Groen, A A. Wijers, H Noltes, O Tucha… - …, 2016 - Springer
Objective The study investigated whether baseline plasma oxytocin (OXT) concentrations
might moderate the effects of nasally administered OXT on social orienting. Methods Thirty …