Kappa free light chain (KFLC) index, a measure for intrathecal production of free kappa
chains, has been increasingly recognized for its diagnostic potential in multiple sclerosis …

Background Automated, technically simple analytical methods offering objective results are
highly valued in clinical laboratories. Kappa free light chains (KFLC) in cerebrospinal fluid …

Background and Objectives Kappa free light chains (KFLC) seem to efficiently diagnose MS.
However, extensive cohort studies are lacking to establish consensus cut-offs, notably to …

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous
system. Previous studies have shown that cerebrospinal fluid (CSF) kappa free light chains …

Cerebrospinal fluid (CSF) kappa free light chain (KFLC) index has been described as a
reliable marker of intrathecal IgG synthesis to diagnose multiple sclerosis (MS). Our aims …

Background: Kappa free light chains (KFLCs) have been proposed as a diagnostic
biomarker in patients with clinically isolated syndrome (CIS) and multiple sclerosis (MS) …

Objective: To validate kappa free light chain (KFLC) and lambda free light chain (LFLC)
indices as a diagnostic biomarker in multiple sclerosis (MS). Methods: We performed a …

Free light chains (FLC) are a promising biomarker to detect intrathecal inflammation in
patients with inflammatory central nervous system (CNS) diseases, including multiple …

Background: Oligoclonal bands represent intrathecal immunoglobulin G (IgG) synthesis and
play an important role in the diagnosis of multiple sclerosis (MS). Kappa free light chains …

Multiple sclerosis (MS) is a chronic immune-mediated disorder of the central nervous system
that shows a high interindividual heterogeneity, which frequently poses challenges …