High-altitude cerebral hypoxia promotes mitochondrial dysfunction and apoptosis of mouse neurons
Y Huan, H Quan, B Jia, G Hao, Z Shi, T Zhao… - Frontiers in Molecular …, 2023 - frontiersin.org
Introduction Neuronal cell death is an important factor in the pathogenesis of acute high-
altitude cerebral hypoxia; however, the underlying molecular mechanism remains unclear …
altitude cerebral hypoxia; however, the underlying molecular mechanism remains unclear …
Establishment and evaluation of a simulated high‑altitude hypoxic brain injury model in SD rats
Y Hou, X Wang, X Chen, J Zhang… - Molecular …, 2019 - spandidos-publications.com
This study was conducted to establish a stable hypobaric hypoxia brain injury model. SD
rats were randomly separated into control and model groups, and placed outside or inside of …
rats were randomly separated into control and model groups, and placed outside or inside of …
Time-course effects and mechanisms of hypobaric hypoxia on nervous system in mice
H Zhang, X Zhang, Z Liu, Y Mei, Y Liu, X Wei, C Xiao… - Neuroscience …, 2023 - Elsevier
Objective The aim of this study was to investigate the effect of time course on neurological
impairment after acute hypobaric hypoxia exposure in mice and clarify the mechanism of …
impairment after acute hypobaric hypoxia exposure in mice and clarify the mechanism of …
Acute high-altitude hypoxic brain injury: Identification of ten differential proteins
J Li, Y Qi, H Liu, Y Cui, L Zhang, H Gong… - Neural Regeneration …, 2013 - journals.lww.com
Hypobaric hypoxia can cause severe brain damage and mitochondrial dysfunction, and is
involved in hypoxic brain injury. However, little is currently known about the mechanisms …
involved in hypoxic brain injury. However, little is currently known about the mechanisms …
Hypobaric hypoxia damages the hippocampal pyramidal neurons in the rat brain
P Maiti, SB Singh, S Muthuraju, S Veleri, G Ilavazhagan - Brain research, 2007 - Elsevier
Hypobaric hypoxia (HH), a predisposing environmental condition at high altitude (HA),
encountered by many mountaineers, jeopardizes their normal physiology like motor …
encountered by many mountaineers, jeopardizes their normal physiology like motor …
Impairment of autophagic flux after hypobaric hypoxia potentiates oxidative stress and cognitive function disturbances in mice
S Dai, Y Feng, C Lu, H Zhang, W Ma, W Xie, X Wu… - Neuroscience …, 2024 - Springer
Acute hypobaric hypoxic brain damage is a potentially fatal high-altitude sickness.
Autophagy plays a critical role in ischemic brain injury, but its role in hypobaric hypoxia (HH) …
Autophagy plays a critical role in ischemic brain injury, but its role in hypobaric hypoxia (HH) …
Brain-aging related protein expression and imaging characteristics of mice exposed to chronic hypoxia at high altitude
Y Cao, S Cao, RL Ge, H Bao, Y Mou… - Frontiers in Aging …, 2023 - frontiersin.org
Objective To determine changes in protein expression related to brain aging and imaging
features in mice after chronic hypoxia exposure at high altitude. Method A total of 24 healthy …
features in mice after chronic hypoxia exposure at high altitude. Method A total of 24 healthy …
Hydrogen ameliorates chronic intermittent hypoxia-induced neurocognitive impairment via inhibiting oxidative stress
W Li, S Yang, FY Yu, Y Zhao, ZM Sun, JR An, E Ji - Brain Research Bulletin, 2018 - Elsevier
Obstructive sleep apnea (OSA) is a very common breathing and sleep disorder
characterized by intermittent hypoxia (IH), which is often associated with behavioral and …
characterized by intermittent hypoxia (IH), which is often associated with behavioral and …
Insight into the Effects of High‐Altitude Hypoxic Exposure on Learning and Memory
Z Zhang, Y Sun, Z Yuan, L Wang… - Oxidative Medicine …, 2022 - Wiley Online Library
The earth land area is heterogeneous in terms of elevation; about 45% of its land area
belongs to higher elevation with altitude above 500 meters compared to sea level. In most …
belongs to higher elevation with altitude above 500 meters compared to sea level. In most …
Temporal and spatial changes in glial cells during chronic hypobaric hypoxia: role in neurodegeneration
Ascend to high altitude results in a drastic change in the environmental conditions an
individual is exposed to. As the altitude increases there is a decrease in partial pressure of …
individual is exposed to. As the altitude increases there is a decrease in partial pressure of …
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