ECM regulates MT1-MMP localization with β1 or αvβ3 integrins at distinct cell compartments modulating its internalization and activity on human endothelial cells

BG Gálvez, S Matías-Román, M Yáñez-Mó… - The Journal of cell …, 2002 - rupress.org
Regulation of membrane-type 1 matrix metalloproteinase (MT1-MMP) by different
extracellular matrices (ECMs) on human endothelial cells (ECs) has been investigated. First …

[HTML][HTML] Membrane type 1-matrix metalloproteinase is activated during migration of human endothelial cells and modulates endothelial motility and matrix remodeling

BG Gálvez, S Matı́as-Román, JP Albar… - Journal of Biological …, 2001 - ASBMB
Matrix metalloproteinases are thought to play an important role in endothelial cell migration
and matrix remodeling. We have used an in vitro wound healing migration model and newly …

Adhesion-dependent control of matrix metalloproteinase-2 activation in human capillary endothelial cells

L Yan, MA Moses, S Huang… - Journal of cell …, 2000 - journals.biologists.com
The growth and regression of capillary blood vessels during angiogenesis is greatly
influenced by changes in the activity of matrix metalloproteinases (MMPs), which selectively …

Membrane type 1–matrix metalloproteinase is involved in migration of human monocytes and is regulated through their interaction with fibronectin or endothelium

S Matías-Román, BG Gálvez, L Genís, M Yáñez-Mó… - Blood, 2005 - ashpublications.org
Membrane type 1–matrix metalloproteinase (MT1-MMP) is involved in endothelial and tumor-
cell migration, but its putative role in leukocyte migration has not been characterized yet …

MT1‐MMP, but not secreted MMPs, influences the migration of human microvascular endothelial cells in 3‐dimensional collagen gels

T Koike, RB Vernon, MA Hamner… - Journal of cellular …, 2002 - Wiley Online Library
Matrix metalloproteinases (MMPs) and their specific inhibitors the TIMPs play significant
roles in angiogenesis. We investigated how the expression of specific MMPs and TIMPs by …

Membrane-type 1 matrix metalloproteinase modulates focal adhesion stability and cell migration

T Takino, Y Watanabe, M Matsui, H Miyamori… - Experimental cell …, 2006 - Elsevier
Membrane-type 1 matrix metalloproteinase (MT1-MMP) plays an important role in
extracellular matrix-induced cell migration and the activation of extracellular signal …

MT1‐MMP and integrins: Hand‐to‐hand in cell communication

P Gonzalo, V Moreno, BG Gálvez, AG Arroyo - Biofactors, 2010 - Wiley Online Library
Integrins are transmembrane adhesion receptors essential for cell communication with the
environment and in particular with the extracellular matrix (ECM). ECM components can be …

Perivascular cells regulate endothelial membrane type-1 matrix metalloproteinase activity

MA Lafleur, PA Forsyth, SJ Atkinson, G Murphy… - Biochemical and …, 2001 - Elsevier
Angiogenic stimuli selectively induced expression of membrane type-1 matrix
metalloproteinase (MT1-MMP) transcripts and protein in human umbilical vein endothelial …

[HTML][HTML] Membrane type 1-matrix metalloproteinase is regulated by chemokines monocyte-chemoattractant protein-1/ccl2 and interleukin-8/CXCL8 in endothelial cells …

BG Gálvez, L Genís, S Matías-Román… - Journal of Biological …, 2005 - ASBMB
We have investigated the putative role and regulation of membrane type 1-matrix
metalloproteinase (MT1-MMP) in angiogenesis induced by inflammatory factors of the …

[HTML][HTML] Up-regulation of vascular endothelial growth factor-A by active membrane-type 1 matrix metalloproteinase through activation of Src-tyrosine kinases

NE Sounni, C Roghi, V Chabottaux, M Janssen… - Journal of Biological …, 2004 - ASBMB
Membrane-type 1 matrix metalloproteinase (MT1-MMP) and vascular endothelial growth
factor (VEGF) are two key molecules involved in pericellular proteolysis and cell proliferation …