Peroxisomal membrane proteins contain common Pex19p-binding sites that are an integral part of their targeting signals

H Rottensteiner, A Kramer, S Lorenzen… - Molecular biology of …, 2004 - Am Soc Cell Biol
Targeting of peroxisomal membrane proteins (PMPs) is a multistep process that requires not
only recognition of PMPs in the cytosol but also their insertion into the peroxisomal …

The peroxisomal receptor Pex19p forms a helical mPTS recognition domain

N Schueller, SJ Holton, K Fodor, M Milewski… - The EMBO …, 2010 - embopress.org
The protein Pex19p functions as a receptor and chaperone of peroxisomal membrane
proteins (PMPs). The crystal structure of the folded C‐terminal part of the receptor reveals a …

[HTML][HTML] Targeting signals in peroxisomal membrane proteins

E Van Ael, M Fransen - Biochimica et Biophysica Acta (BBA)-Molecular …, 2006 - Elsevier
Peroxisomal membrane proteins (PMPs) are encoded by the nuclear genome and
translated on cytoplasmic ribosomes. Newly synthesized PMPs can be targeted directly from …

PEX19 is a predominantly cytosolic chaperone and import receptor for class 1 peroxisomal membrane proteins

JM Jones, JC Morrell, SJ Gould - The Journal of cell biology, 2004 - rupress.org
Integral peroxisomal membrane proteins (PMPs) are synthesized in the cytoplasm and
imported posttranslationally. Here, we demonstrate that PEX19 binds and stabilizes newly …

Multiple distinct targeting signals in integral peroxisomal membrane proteins

JM Jones, JC Morrell, SJ Gould - The Journal of Cell Biology, 2001 - rupress.org
Peroxisomal proteins are synthesized on free polysomes and then transported from the
cytoplasm to peroxisomes. This process is mediated by two short well-defined targeting …

The N-domain of Pex22p can functionally replace the Pex3p N-domain in targeting and peroxisome formation

A Halbach, R Rucktäschel, H Rottensteiner… - Journal of Biological …, 2009 - ASBMB
Pex3p is a central component of the import machinery for peroxisomal membrane proteins
(PMPs) that can reach peroxisomes via the endoplasmic reticulum (ER) and even trigger de …

Potential role for Pex19p in assembly of PTS-receptor docking complexes

M Fransen, I Vastiau, C Brees, V Brys… - Journal of Biological …, 2004 - ASBMB
Human Pex19p binds a broad spectrum of peroxisomal membrane proteins (PMPs). It has
been proposed that this peroxin may:(i) act as a cycling PMP receptor protein,(ii) facilitate …

[HTML][HTML] Targeting of the 22 kDa integral peroxisomal membrane protein

B Pause, R Saffrich, A Hunziker, W Ansorge, WW Just - Febs Letters, 2000 - Elsevier
Investigating targeting of the 22 kDa peroxisomal membrane protein (Pmp22p) to the
peroxisomal membrane we have confined the targeting signal to amino acid residues 16–37 …

[HTML][HTML] Mammalian Pex14p: membrane topology and characterisation of the Pex14p–Pex14p interaction

MEM Oliveira, C Reguenga, AMM Gouveia… - … et Biophysica Acta (BBA …, 2002 - Elsevier
Peroxisomal biogenesis is a complex process requiring the action of numerous peroxins.
One central component of this machinery is Pex14p, an intrinsic peroxisomal membrane …

The import competence of a peroxisomal membrane protein is determined by Pex19p before the docking step

MP Pinto, CP Grou, IS Alencastre, ME Oliveira… - Journal of Biological …, 2006 - ASBMB
Biogenesis of the mammalian peroxisomal membrane requires the action of Pex3p and
Pex16p, two proteins present in the organelle membrane, and Pex19p, a protein that …