Parasites of the genus Leishmania cause a variety of devastating and often fatal diseases in
humans and domestic animals worldwide. The need for new therapeutic strategies is urgent …

Molecular, biochemical and genetic characterization of ornithine decarboxylase, S-
adenosylmethionine decarboxylase and spermidine synthase establishes that these …

ABSTRACT A number of anticancer and antiparasitic drugs are postulated to target the
polyamine biosynthetic pathway and polyamine function, but the exact mode of action of …

Polyamines (PAs) are essential metabolites in eukaryotes, participating in a variety of
proliferative processes, and in trypanosomatid protozoa play an additional role in the …

Polyamines are metabolites that play important roles in rapidly proliferating cells, and recent
studies have highlighted their critical nature in Leishmania parasites. However, little is …

The polyamine biosynthetic pathway of protozoan parasites has been validated as a target
in antiparasitic chemotherapy. To investigate this pathway at the biochemical and genetic …

Leishmaniasis is a major public health problem and till date there are no effective vaccines
available. The control strategy relies solely on chemotherapy of the infected people …

Polyamines are positively-charged organic molecules that are important for cellular growth
and division. Polyamines and their synthesizing enzymes are particularly abundant in …

Leishmaniasis is a neglected disease affecting more than 12 million people worldwide. The
most used drugs are pentavalent antimonials that are very toxic and display the problem of …

Tegumentary leishmaniasis (TL) is a parasitic disease that can result in wide spectrum
clinical manifestations. It is necessary to understand host and parasite determinants of …