Exploring the interplay between triple‐negative breast cancer stem cells and tumor microenvironment for effective therapeutic strategies

Z Zou, T Luo, X Wang, B Wang… - Journal of Cellular …, 2024 - Wiley Online Library
Triple‐negative breast cancer (TNBC) is a highly aggressive and metastatic malignancy with
poor treatment outcomes. The interaction between the tumor microenvironment (TME) and …

From interaction to intervention: how mesenchymal stem cells affect and target triple-negative breast cancer

Y Wu, HCE Shum, K Wu, J Vadgama - Biomedicines, 2023 - mdpi.com
Triple-negative breast cancer (TNBC) lacks estrogen receptor, progesterone receptor, and
human epidermal growth factor receptor 2 expressions, making targeted therapies …

The role of breast cancer stem cells in chemoresistance and metastasis in triple-negative breast cancer

L He, N Wick, SK Germans, Y Peng - Cancers, 2021 - mdpi.com
Simple Summary Triple negative breast cancer lacks targeted therapies and has poor
prognosis; chemotherapy is currently the main treatment modality. Growing evidence has …

[HTML][HTML] Regulation of cancer stem cells in triple negative breast cancer

N Fultang, M Chakraborty… - Cancer Drug …, 2021 - ncbi.nlm.nih.gov
Abstract Triple Negative Breast Cancer (TNBC) is the most lethal subtype of breast cancer.
Despite the successes of emerging targeted therapies, relapse, recurrence, and therapy …

[HTML][HTML] Targeting cancer stem cell plasticity in triple-negative breast cancer

Z Guo, S Han - Exploration of Targeted Anti-tumor Therapy, 2023 - ncbi.nlm.nih.gov
Triple-negative breast cancer (TNBC) is a highly aggressive breast cancer subtype with
limited treatment options. Cancer stem cells (CSCs) are thought to play a crucial role in …

Signaling pathways essential for triple-negative breast cancer stem-like cells

S Ehmsen, HJ Ditzel - Stem Cells, 2021 - academic.oup.com
Since the discovery of breast cancer stem cells (CSCs), a significant effort has been made to
identify and characterize these cells. It is a generally believe that CSCs play an important …

Targeting cancer stem cells in triple-negative breast cancer

SY Park, JH Choi, JS Nam - Cancers, 2019 - mdpi.com
Triple-negative breast cancer (TNBC) is a highly aggressive form of breast cancer that lacks
targeted therapy options, and patients diagnosed with TNBC have poorer outcomes than …

Chemotherapeutic stress influences epithelial–mesenchymal transition and stemness in cancer stem cells of triple-negative breast cancer

X Li, J Strietz, A Bleilevens, E Stickeler… - International journal of …, 2020 - mdpi.com
Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by the
absence of estrogen and progesterone receptors (ER, PR) and lacking an overexpression of …

The tumor microenvironment and triple-negative breast cancer aggressiveness: shedding light on mechanisms and targeting

N Furukawa, V Stearns, CA Santa-Maria… - Expert opinion on …, 2022 - Taylor & Francis
Introduction In contrast to other breast cancer subtypes, there are currently limited options of
targeted therapies for triple-negative breast cancer (TNBC). Immense research has …

[HTML][HTML] VEGFA/NRP-1/GAPVD1 axis promotes progression and cancer stemness of triple-negative breast cancer by enhancing tumor cell-macrophage crosstalk

L Wang, L Zhang, L Zhao, S Shao, Q Ning… - … Journal of Biological …, 2024 - ncbi.nlm.nih.gov
Triple-negative breast cancer (TNBC) has long been considered a major clinical challenge
due to its aggressive behavior and poor prognosis. Cancer stem cells (CSCs) are known as …