Antibodies secreted at the mucosal surface play an integral role in immune defense by
serving to neutralize the pathogen and promote its elimination at the site of entry. Secretory …

Intranasal (in) immunization aims to induce local as well as systemic immune responses. In
the present study, we assessed a vaccine platform based on virus‐like particles (VLP) …

Abstract Mucosal IgA or secretory IgA (SIgA) are structurally equipped to resist chemical
degradation in the harsh environment of mucosal surfaces and enzymes of host or microbial …

After pulmonary virus infection, virus-binding B cells ectopically accumulate in the lung.
However, their contribution to protective immunity against reinfecting viruses remains …

This study examined whether secretory IgA (S‐IgA) antibodies (Abs) could confer cross‐
protective immunity against infection with influenza B viruses of antigenically distinct …

INTRODUCTION Immunoglobulin A (IgA) is the most abundant mammalian antibody
isotype, constituting more than 80% of all antibody-secreting plasma cells at steady state …

IgA is the most prevalent antibody type on mucosal surfaces and the second most prevalent
antibody in circulation, yet its role in immune defense is not fully understood. Here we show …

Mucosal surfaces are colonized by large communities of commensal bacteria and represent
the primary site of entry for pathogenic agents. To prevent microbial intrusion, mucosal B …

Mucosal vaccination via the respiratory tract can elicit protective immunity in animal infection
models, but the underlying mechanisms are still poorly understood. We show that a single …

IgA is the predominant Ig isotype in mucosal tissue and is believed to be involved in defense
against viral and bacterial infections at these sites. Here, we examined the role of IgA in the …