The diverse functions of GAPDH: views from different subcellular compartments

C Tristan, N Shahani, TW Sedlak, A Sawa - Cellular signalling, 2011 - Elsevier
Multiple roles for glyceraldehyde-3-phosphate dehydrogenase (GAPDH) have been recently
appreciated. In addition to the cytoplasm where the majority of GAPDH is located under the …

New insights into an old protein: the functional diversity of mammalian glyceraldehyde-3-phosphate dehydrogenase

MA Sirover - Biochimica et Biophysica Acta (BBA)-Protein Structure …, 1999 - Elsevier
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was considered a classical
glycolytic protein examined for its pivotal role in energy production. It was also used as a …

GAPDH: a common enzyme with uncommon functions

C Nicholls, H Li, JP Liu - Clinical and Experimental …, 2012 - Wiley Online Library
Glyceraldehyde‐3‐phosphate dehydrogenase (GAPDH) has long been recognized as an
important enzyme for energy metabolism and the production of ATP and pyruvate through …

[HTML][HTML] GAPDH as a sensor of NO stress

MR Hara, MB Cascio, A Sawa - … et Biophysica Acta (BBA)-Molecular Basis …, 2006 - Elsevier
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a classic glycolytic enzyme, and
accumulating evidence has suggested that GAPDH is a multi-functional protein. In particular …

The writers, readers, and erasers in redox regulation of GAPDH

MA Tossounian, B Zhang, I Gout - Antioxidants, 2020 - mdpi.com
Glyceraldehyde 3–phosphate dehydrogenase (GAPDH) is a key glycolytic enzyme, which is
crucial for the breakdown of glucose to provide cellular energy. Over the past decade …

Oxidative modifications of glyceraldehyde-3-phosphate dehydrogenase play a key role in its multiple cellular functions

NR Hwang, SH Yim, YM Kim, J Jeong… - Biochemical …, 2009 - portlandpress.com
Knowledge of the cellular targets of ROS (reactive oxygen species) and their regulation is an
essential prerequisite for understanding ROS-mediated signalling. GAPDH (glyceraldehyde …

Glyceraldehyde-3-phosphate dehydrogenase in neurodegeneration and apoptosis signaling

WG Tatton, RME Chalmers-Redman, M Elstner… - Advances in Research …, 2000 - Springer
Summary Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a well-studied
glycolytic enzyme that plays a key role in energy metabolism. GAPDH catalyzes the …

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) aggregation causes mitochondrial dysfunction during oxidative stress-induced cell death

H Nakajima, M Itakura, T Kubo, A Kaneshige… - Journal of Biological …, 2017 - ASBMB
Glycolytic glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a multifunctional protein
that also mediates cell death under oxidative stress. We reported previously that the active …

Glyceraldehyde-3-phosphate dehydrogenase, apoptosis, and neurodegenerative diseases

DM Chuang, C Hough… - Annu. Rev. Pharmacol …, 2005 - annualreviews.org
▪ Abstract Increasing evidence supports the notion that glyceraldehyde-3-phosphate
dehydrogenase (GAPDH) is a protein with multiple functions, including its surprising role in …

Novel roles for GAPDH in cell death and carcinogenesis

A Colell, DR Green, JE Ricci - Cell Death & Differentiation, 2009 - nature.com
Growing evidence points to the fact that glucose metabolism has a central role in
carcinogenesis. Among the enzymes controlling this energy production pathway …