Physical exercise represents one of the strongest physiological stimuli capable to induce
functional and structural modifications in all biological systems. Indeed, beside the …

Physical exercise is established as an important factor of health and generally is
recommended for its positive effects on several tissues, organs, and systems. These positive …

Exercise-induced adaptation is achieved by altering the epigenetic landscape of the entire
genome leading to the expression of genes involved in various processes including …

The complexity of human DNA has been affected by aerobic metabolism, including
endurance exercise and oxygen toxicity. Aerobic endurance exercise could play an …

Exercise and physical activity induces physiological responses in organisms, and
adaptations in skeletal muscle, which is beneficial for maintaining health and preventing …

Significance: Exercise-induced reactive oxygen species (ROS) production activates multiple
intracellular signaling pathways through genomic and nongenomic mechanisms that are …

Most human phenotypes are influenced by a combination of genomic and environmental
factors. Engaging in regular physical exercise prevents many chronic diseases, decreases …

Exercise imposes cellular stress on contracting skeletal muscle fibers, forcing them to
complete molecular adaptations to maintain homeostasis. There is mounting evidence that …

The equivocal role of reactive species and redox signaling in exercise responses and
adaptations is an example clearly showing the inadequacy of current redox biology research …

Epigenetic modification refers to heritable changes in gene function that cannot be
explained by alterations in the DNA sequence. The current literature clearly demonstrates …