Controlled human infection models to accelerate vaccine development
RKM Choy, AL Bourgeois… - Clinical Microbiology …, 2022 - Am Soc Microbiol
The timelines for developing vaccines against infectious diseases are lengthy, and often
vaccines that reach the stage of large phase 3 field trials fail to provide the desired level of …
vaccines that reach the stage of large phase 3 field trials fail to provide the desired level of …
Human challenge trials in vaccine development
A Sekhar, G Kang - Seminars in Immunology, 2020 - Elsevier
The increasing recent interest in human challenge studies or controlled human infection
model studies for accelerating vaccine development has been driven by the recognition of …
model studies for accelerating vaccine development has been driven by the recognition of …
The current challenges for vaccine development
P Oyston, K Robinson - Journal of medical microbiology, 2012 - microbiologyresearch.org
Vaccine development has played a hugely important role in combating infectious disease.
Despite this success, there is still a great need for new vaccines and these are emerging far …
Despite this success, there is still a great need for new vaccines and these are emerging far …
How advances in immunology provide insight into improving vaccine efficacy
MK Slifka, I Amanna - Vaccine, 2014 - Elsevier
Vaccines represent one of the most compelling examples of how biomedical research has
improved society by saving lives and dramatically reducing the burden of infectious disease …
improved society by saving lives and dramatically reducing the burden of infectious disease …
[HTML][HTML] How can controlled human infection models accelerate clinical development and policy pathways for vaccines against Shigella?
BK Giersing, CK Porter, K Kotloff, P Neels, A Cravioto… - Vaccine, 2019 - Elsevier
Abstract Controlled Human Infection Models (CHIMs) now exist for several infectious
diseases. CHIMs offer significant insight into disease pathogenesis, as well the potential to …
diseases. CHIMs offer significant insight into disease pathogenesis, as well the potential to …
Increasing complexity of vaccine development
SA Plotkin - The Journal of infectious diseases, 2015 - academic.oup.com
Vaccines already developed have been enormously successful. However, the development
of future vaccines requires solution of a number of immunologic problems, including …
of future vaccines requires solution of a number of immunologic problems, including …
Waning immunity and microbial vaccines—workshop of the National Institute of Allergy and Infectious Diseases
XX Gu, SA Plotkin, KM Edwards, A Sette… - Clinical and Vaccine …, 2017 - Am Soc Microbiol
Since the middle of the 20th century, vaccines have made a significant public health impact
by controlling infectious diseases globally. Although long-term protection has been achieved …
by controlling infectious diseases globally. Although long-term protection has been achieved …
Use of animal models in the development of human vaccines
V Gerdts, SD Littel-van den Hurk, PJ Griebel… - Future …, 2007 - Taylor & Francis
Over the past 100 years, animal infectious disease research has played a crucial role in the
development of human vaccines. In fact, many of today's vaccines are based on utilizing …
development of human vaccines. In fact, many of today's vaccines are based on utilizing …
Controlled human infections as a tool to reduce uncertainty in clinical vaccine development
M Roestenberg, IMC Kamerling, SJ De Visser - Frontiers in medicine, 2018 - frontiersin.org
Vaccines can be extremely cost-effective public health measures. Unfortunately the research
and development (R&D) of novel vaccines is suffering from rising costs and declining …
and development (R&D) of novel vaccines is suffering from rising costs and declining …
Principles of vaccine design—lessons from nature
F Zepp - Vaccine, 2010 - Elsevier
Microbial pathogens have developed complex and efficient ways of counteracting and
evading innate and adaptive immune mechanisms. The strategies used by pathogens …
evading innate and adaptive immune mechanisms. The strategies used by pathogens …