Dendritic arborization is required for proper neuronal connectivity. Rho GTPases have been
implicated in the regulation of dendrite development. However, the signaling pathways that …

Regulated growth and arborization of dendritic processes are critical to the formation of
functional neuronal networks. Here we identify β-catenin as a critical mediator of dendritic …

Wnt signaling controls a variety of developmental and homeostatic events. As a key
component of Wnt signaling, Dishevelled (Dvl/Dsh) protein relays Wnt signals from receptors …

Previously, we have shown that Wnt-5a strongly regulates dopaminergic neuron
differentiation by inducing phosphorylation of Dishevelled (Dvl). Here, we identify additional …

The balance between excitatory and inhibitory synapses is crucial for normal brain function.
Wnt proteins stimulate synapse formation by increasing synaptic assembly. However, it is …

The atypical protein kinase C (aPKC) in complex with PAR3 and PAR6 is required for axon-
dendrite differentiation, but the upstream factors responsible for regulating its activity are …

Members of the Wnt signaling family are important mediators of numerous developmental
events, including activity-dependent dendrite development, but the pathways regulating …

Wnt signaling is critical to many aspects of development, and aberrant activation of the Wnt
signaling pathway can cause cancer. Dishevelled (Dvl) protein plays a central role in this …

Background Wnt factors are a large family of signaling molecules that play important roles in
the regulation of cell fate specification, tissue polarity and cell movement. In the nervous …

Stability of neuronal connectivity is critical for brain functions, and morphological
perturbations are associated with neurodegenerative disorders. However, how neuronal …