Nerve density in the epidermis is partly involved in itch sensitization in pruritic skin diseases,
such as atopic dermatitis (AD). Epidermal innervation is thought to be regulated by the …

Histamine H 1-receptor blockers are used to treat all types of itch resulting from serious skin
diseases such as atopic dermatitis, as well as from renal and liver diseases. However, they …

BACKGROUND: Epidermal hyperinnervation in atopic dermatitis (AD) is activated directly by
various external stimuli, causing enhanced itching. Nerve density is regulated by the nerve …

BACKGROUND: Epidermal nerve densities are increased in patients with atopic dermatitis
(AD), suggesting that it is partly responsible for the intense itching in the skin. Epidermal …

Topical steroids and antihistamines are commonly used for the treatment of atopic dermatitis
(AD). However, in a substantial number of patients with AD, these treatments are not …

Itch, the hallmark of atopic dermatitis, has a significant impact on quality of life for patients
with this disease. Various central and peripheral mediators have been suggested to play a …

Background Psoriasis is a complex, multifactorial inflammatory skin disease with genetic
and environmental interactions. Patients with psoriasis exhibit erythematous plaques with …

Itching is defined as an unpleasant cutaneous sensation leading to the desire to scratch. It
serves as a physiological self-protective mechanism as do other cutaneous sensations like …

Pruritus is an essential feature of atopic dermatitis (AD) and the diagnosis of active AD
cannot be made without the history of itching. Because of the high impact on life quality …

Medicine, Yokohama, Japan (notice of approval IRB protocol number B080911013). written
informed consent was obtained from all participants. A total of 61 patients with psoriasis and …