The need for new antimicrobials is great in face of a growing pool of resistant pathogenic
organisms. This review will address the potential for antimicrobial therapy based on …

Folate biosynthesis remains a key target for antimicrobial therapy. Folate is an essential
vitamin (vitamin B9) that is required for many one-carbon transfer reactions and is a critical …

Folate pathway is a key target for the development of new drugs against infectious diseases
since the discovery of sulfa drugs and trimethoprim. The knowledge about this pathway has …

Over the past six decades, the folate biosynthetic pathway has provided a rich source of
drug targets for the treatment of proliferative diseases. Drugs targeting dihydrofolate …

The potential of the folic acid biosynthesis pathway as a target for the development of
antibiotics has been acknowledged for many years and validated by the clinical use of …

Reduced folate derivatives participate in numerous reactions of bacterial intermediary
metabolism. Consequently, the well-characterized enzyme implicated in the formation of …

Dihydrofolate reductase (DHFR) plays an essential role in cellular biochemistry and has
been a wellrecognized drug target for over fifty years. Antifolate inhibitors of DHFR, including …

In some bacteria, such as Escherichia coli, the addition of l-glutamate to dihydropteroate
(dihydrofolate synthetase activity) and the subsequent additions of l-glutamate to …

Drug-resistant bacteria pose an increasingly serious threat to mankind all over the world.
However, the currently available clinical treatments do not meet the urgent demand …

The sulfonamide antibiotics inhibit dihydropteroate synthase (DHPS), a key enzyme in the
folate pathway of bacteria and primitive eukaryotes. However, resistance mutations have …