Background and objectives: Non-aggregated protamine impregnated poly (lactide-co-
glycolide) nanoparticles of cisplatin (Pt-PLGA NPs) were synthesized to augment brain …

Aim The aim of this study was to improve the therapeutic index of chemotherapeutic drugs
on glioblastoma cells through an improved co-drug delivery system. Materials and methods …

The aims of this study were to develop and characterize curcumin (CCM) and docetaxel
(DTX) co-loaded poly lactide-co-glycolide (PLGA) nanoparticles (NPs) to overcome blood …

Malignant gliomas are highly lethal. Delivering chemotherapeutic drugs to the brain in
sufficient concentration is the major limitation in their treatment due to the blood-brain barrier …

Surface-modified poly (d, l-lactic-co-glycolic acid) PLGA nanoparticles (NPs) were fabricated
via nanoprecipitation for obtaining therapeutic concentration of paclitaxel (PTX) in brain …

The aim of this work is to co-load paclitaxel (PTX) and etoposide (ETP) in methoxy poly
(ethylene glycol)-poly (lactic-co-glycolic acid) nanoparticles (mPEG-PLGA NPs) to overcome …

The carboplatin (CP) loaded poly-lactide-co-glycolide (PLGA) nanoparticles (NPs) were
formulated by modified solvent evaporation method. Its surface modification is done by 1 …

For a nanoparticulate drug-delivery system, crucial challenges in brain-glioblastoma therapy
are its poor penetration and retention in the glioblastoma parenchyma. As a prevailing …

The development of multidrug resistance (due to drug efflux by P-glycoproteins) is a major
drawback with the use of paclitaxel (PTX) in the treatment of cancer. The rationale behind …

Background Chemotherapy of glioblastoma is largely ineffective as the blood-brain barrier
(BBB) prevents entry of most anticancer agents into the brain. For an efficient treatment of …