Obesity is associated with resistance of skeletal muscle to insulin-mediated glucose uptake,
as well as resistance of different organs and tissues to other metabolic and vascular actions …

The metabolic functionality of adipose tissue is intimately dependent on local
communication between various cell types. It influences not only the equilibrium between …

Adipose tissue constitutes an extremely active endocrine organ with a network of signaling
pathways enabling the organism to adapt to a wide range of different metabolic challenges …

Adipose tissue is highly versatile, dynamic and essential for metabolic health. In 2022,
several exciting discoveries provided a high-resolution view of cellular composition and cell …

White adipose tissue (WAT) is a major endocrine and secretory organ, which releases a
wide range of protein signals and factors termed adipokines. A number of adipokines …

The discovery of adipokines has revealed adipose tissue as a central node in the interorgan
crosstalk network, which mediates the regulation of multiple organs and tissues. Adipose …

Adipose tissue is a complex endocrine organ with an intricate role in whole body
homeostasis. Beyond storing energy, adipose tissue is fundamental in numerous processes …

The prevalence of obesity and diabetes is rising to epidemic proportions worldwide. Insulin
resistance is central to the pathogenesis of type 2 diabetes. The role of insulin sensitive …

Adipose tissue not only has an important role in the storage of excess nutrients but also
senses nutrient status and regulates energy mobilization. An overall positive energy balance …

Several lines of preclinical and clinical research have confirmed that chronic low-grade
inflammation of adipose tissue is mechanistically linked to metabolic disease and organ …