A tandem mass spectrometry assay for the simultaneous determination of acetaminophen, caffeine, phenytoin, ranitidine, and theophylline in small volume pediatric …
Y Zhang, N Mehrotra, NR Budha, ML Christensen… - Clinica chimica acta, 2008 - Elsevier
BACKGROUND: Acetaminophen, caffeine, phenytoin, ranitidine, and theophylline are
widely used in pediatric pharmacotherapy, but only very limited information is available on …
widely used in pediatric pharmacotherapy, but only very limited information is available on …
Simultaneous quantification of acetaminophen and five acetaminophen metabolites in human plasma and urine by high-performance liquid chromatography …
SF Cook, AD King, JN van den Anker… - … of Chromatography B, 2015 - Elsevier
Drug metabolism plays a key role in acetaminophen (paracetamol)-induced hepatotoxicity,
and quantification of acetaminophen metabolites provides critical information about factors …
and quantification of acetaminophen metabolites provides critical information about factors …
Comparison of the quantification of acetaminophen in plasma, cerebrospinal fluid and dried blood spots using high-performance liquid chromatography–tandem mass …
RR Taylor, KL Hoffman, B Schniedewind… - … of pharmaceutical and …, 2013 - Elsevier
Acetaminophen (paracetamol, N-(4-hydroxyphenyl) acetamide) is one of the most commonly
prescribed drugs for the management of pain in children. Quantification of acetaminophen in …
prescribed drugs for the management of pain in children. Quantification of acetaminophen in …
Pediatric Microdose Study of [14C]Paracetamol to Study Drug Metabolism Using Accelerated Mass Spectrometry: Proof of Concept
MG Mooij, E van Duijn, CAJ Knibbe… - Clinical …, 2014 - Springer
Background Pediatric drug development is hampered by practical, ethical, and scientific
challenges. Microdosing is a promising new method to obtain pharmacokinetic data in …
challenges. Microdosing is a promising new method to obtain pharmacokinetic data in …
Quantification of acetaminophen (paracetamol) in human plasma and urine by stable isotope-dilution GC–MS and GC–MS/MS as pentafluorobenzyl ether derivative
A Trettin, AA Zoerner, A Böhmer, FM Gutzki… - … of Chromatography B, 2011 - Elsevier
We report on the quantitative determination of acetaminophen (paracetamol; NAPAP-d0) in
human plasma and urine by GC–MS and GC–MS/MS in the electron-capture negative-ion …
human plasma and urine by GC–MS and GC–MS/MS in the electron-capture negative-ion …
Exposure to acetaminophen and all its metabolites upon 10, 15, and 20 mg/kg intravenous acetaminophen in very-preterm infants
RB Flint, DW Roofthooft, A van Rongen… - Pediatric …, 2017 - nature.com
Background Exposure to acetaminophen and its metabolites in very-preterm infants is partly
unknown. We investigated the exposure to acetaminophen and its metabolites upon 10, 15 …
unknown. We investigated the exposure to acetaminophen and its metabolites upon 10, 15 …
A reliable method of liquid chromatography for the quantification of acetaminophen and identification of its toxic metabolite N‐acetyl‐p‐benzoquinoneimine for …
C Flores‐Pérez, JL Chávez‐Pacheco… - Biomedical …, 2011 - Wiley Online Library
The aim of the present study was to develop a simple, selective and reliable method to
quantify acetaminophen and its toxic metabolite N‐acetyl‐p‐benzoquinoneimine (NAPQI) …
quantify acetaminophen and its toxic metabolite N‐acetyl‐p‐benzoquinoneimine (NAPQI) …
Observational infant exploratory [14C]‐paracetamol pharmacokinetic microdose/therapeutic dose study with accelerator mass spectrometry bioanalysis
CR Garner, KB Park, NS French… - British journal of …, 2015 - Wiley Online Library
Aims The aims of the study were to compare [14C]‐paracetamol ([14C]‐PARA) paediatric
pharmacokinetics (PK) after administration mixed in a therapeutic dose or an isolated …
pharmacokinetics (PK) after administration mixed in a therapeutic dose or an isolated …
Gas chromatographic–mass spectrometric quantitation of theophylline and its metabolites in biological fluids
KY Tserng - Journal of Pharmaceutical Sciences, 1983 - Elsevier
Abstract□ In premature infants, theophylline is converted to caffeine, and the biological half-
life is prolonged. To assess the metabolic alterations of theophylline during development of …
life is prolonged. To assess the metabolic alterations of theophylline during development of …
Successful Use of [14C]Paracetamol Microdosing to Elucidate Developmental Changes in Drug Metabolism
MG Mooij, E van Duijn, CAJ Knibbe, K Allegaert… - Clinical …, 2017 - Springer
Background We previously showed the practical and ethical feasibility of using [14 C]-
microdosing for pharmacokinetic studies in children. We now aimed to show that this …
microdosing for pharmacokinetic studies in children. We now aimed to show that this …