Does neuroinflammation fan the flame in neurodegenerative diseases?

TC Frank-Cannon, LT Alto, FE McAlpine… - Molecular …, 2009 - Springer
While peripheral immune access to the central nervous system (CNS) is restricted and tightly
controlled, the CNS is capable of dynamic immune and inflammatory responses to a variety …

Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression

HM Gao, JS Hong - Trends in immunology, 2008 - cell.com
Neurodegenerative diseases are a group of chronic, progressive disorders characterized by
the gradual loss of neurons in discrete areas of the central nervous system (CNS). The …

Mechanisms underlying inflammation in neurodegeneration

CK Glass, K Saijo, B Winner, MC Marchetto, FH Gage - Cell, 2010 - cell.com
Inflammation is associated with many neurodegenerative diseases, including Alzheimer's
disease, Parkinson's disease, amyotrophic lateral sclerosis, and multiple sclerosis. In this …

The benefits of neuroinflammation for the repair of the injured central nervous system

HYF Yong, KS Rawji, S Ghorbani, M Xue… - Cellular & molecular …, 2019 - nature.com
Inflammation of the nervous system (neuroinflammation) is now recognized as a hallmark of
virtually all neurological disorders. In neuroinflammatory conditions such as multiple …

Inflammation in the early stages of neurodegenerative pathology

PJ Khandelwal, AM Herman, CEH Moussa - Journal of neuroimmunology, 2011 - Elsevier
Inflammation is secondary to protein accumulation in neurodegenerative diseases, including
Alzheimer's, Parkinson's and Amyotrophic Lateral Sclerosis. Emerging evidence indicate …

Microglia and neurodegeneration: the role of systemic inflammation

C Cunningham - Glia, 2013 - Wiley Online Library
It is well accepted that CNS inflammation has a role in the progression of chronic
neurodegenerative disease, although the mechanisms through which this occurs are still …

Role of inflammation in neurodegenerative diseases

L Minghetti - Current opinion in neurology, 2005 - journals.lww.com
Although significant advances have been made in our knowledge of degenerative diseases,
there remains controversy regarding whether neuroinflammation and microglial activation …

Neuroinflammation: the devil is in the details

DJ DiSabato, N Quan, JP Godbout - Journal of neurochemistry, 2016 - Wiley Online Library
There is significant interest in understanding inflammatory responses within the brain and
spinal cord. Inflammatory responses that are centralized within the brain and spinal cord are …

Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes

HS Kwon, SH Koh - Translational neurodegeneration, 2020 - Springer
Neuroinflammation is associated with neurodegenerative diseases, such as Alzheimer's
disease, Parkinson's disease, and amyotrophic lateral sclerosis. Microglia and astrocytes …

An inflammation-centric view of neurological disease: beyond the neuron

SD Skaper, L Facci, M Zusso, P Giusti - Frontiers in cellular …, 2018 - frontiersin.org
Inflammation is a complex biological response fundamental to how the body deals with
injury and infection to eliminate the initial cause of cell injury and effect repair. Unlike a …