[HTML][HTML] Sarcopenia–Molecular mechanisms and open questions

P Wiedmer, T Jung, JP Castro, LCD Pomatto… - Ageing research …, 2021 - Elsevier
Sarcopenia represents a muscle-wasting syndrome characterized by progressive and
generalized degenerative loss of skeletal muscle mass, quality, and strength occurring …

[HTML][HTML] Pathophysiology and mechanisms of primary sarcopenia

H Nishikawa, S Fukunishi, A Asai… - International …, 2021 - spandidos-publications.com
Aging causes skeletal muscle atrophy, and myofiber loss can be a critical component of this
process. In 1989, Rosenberg emphasized the importance of the loss of skeletal muscle …

Sarcopenia: molecular pathways and potential targets for intervention

J Pascual-Fernández, A Fernández-Montero… - International Journal of …, 2020 - mdpi.com
Aging is associated with sarcopenia. The loss of strength results in decreased muscle mass
and motor function. This process accelerates the progressive muscle deterioration observed …

Sarcopenia: no consensus, no diagnostic criteria, and no approved indication—How did we get here?

WJ Evans, J Guralnik, P Cawthon, J Appleby, F Landi… - Geroscience, 2024 - Springer
In addition to the role of skeletal muscle in movement and locomotion, muscle plays a critical
role in a broad array of metabolic processes that can contribute to improved health or risk of …

Molecular mechanism and pathogenesis of sarcopenia: An overview

A Picca, R Calvani - International journal of molecular sciences, 2021 - mdpi.com
Sarcopenia involves a progressive age-related decline of skeletal muscle mass and
strength/function [1]. This muscle loss is associated with increased risk of adverse health …

[HTML][HTML] Sarcopenia–endocrinological and neurological aspects

MK Stangl, W Böcker, V Chubanov… - Experimental and …, 2019 - thieme-connect.com
Sarcopenia in geriatric patients is often associated with or even caused by changes of the
endocrine and nervous system. The multifactorial pathogenesis of sarcopenia and …

Sarcopenia: age-related skeletal muscle changes from determinants to physical disability

A Di Iorio, M Abate, D Di Renzo… - International journal …, 2006 - journals.sagepub.com
Human aging is characterized by skeletal muscle wasting, a debilitating condition which sets
the susceptibility for diseases that directly affect the quality of life and often limit life span …

Current understanding of sarcopenia: possible candidates modulating muscle mass

K Sakuma, W Aoi, A Yamaguchi - Pflügers Archiv-European Journal of …, 2015 - Springer
The world's elderly population is expanding rapidly, and we are now faced with the
significant challenge of maintaining or improving physical activity, independence, and …

Models of accelerated sarcopenia: critical pieces for solving the puzzle of age-related muscle atrophy

TW Buford, SD Anton, AR Judge, E Marzetti… - Ageing research …, 2010 - Elsevier
Sarcopenia, the age-related loss of skeletal muscle mass, is a significant public health
concern that continues to grow in relevance as the population ages. Certain conditions have …

[PDF][PDF] Sarcopenia: monitoring, molecular mechanisms, and physical intervention.

A Zembroń-Łacny, W Dziubek… - Physiological …, 2014 - pdfs.semanticscholar.org
Summary According to European Working Group on Sarcopenia in Older People (EWGSOP)
sarcopenia includes both a loss of muscle strength and a decline in functional quality in …