Group II introns are self-splicing ribozymes that catalyze their own excision from precursor
transcripts and insertion into new genetic locations. Here we report the crystal structure of an …

Group II introns are self-splicing, mobile genetic elements that have fundamentally
influenced the organization of terrestrial genomes. These large ribozymes remain important …

Group I self-splicing introns catalyze their own excision from precursor RNAs by way of a two-
step transesterification reaction. The catalytic core of these ribozymes is formed by two …

Group II introns are large, autocatalytic ribozymes that catalyze RNA splicing and
retrotransposition. Splicing by group II introns plays a major role in the metabolism of plants …

Twenty-two years after their discovery as ribozymes, the self-splicing group I introns are
finally disclosing their architecture at the atomic level. The crystal structures of three group I …

Group II introns are large, natural catalytic RNAs or ribozymes that were discovered in
organelles of certain protists, fungi, algae, and plants and more recently also in prokaryotic …

The discovery of the RNA self-splicing group I intron provided the first demonstration that not
all enzymes are proteins. Here we report the X-ray crystal structure (3.1-Å resolution) of a …

Group II introns are self-splicing ribozymes that share a reaction mechanism and a common
ancestor with the eukaryotic spliceosome, thereby providing a model system for …

Group I introns are catalytic RNAs that coordinate two consecutive transesterification
reactions for self-splicing. To understand how the group I intron promotes catalysis and …

Group II introns are some of the largest ribozymes in nature, and they are a major source of
information about RNA assembly and tertiary structural organization. These introns are of …