Martynoside (MAR), a bioactive component in several well-known tonic traditional Chinese
herbs, exhibits pro-hematopoietic activity during 5-fluorouracil (5-FU) treatment. However …

Martynoside (MAR) is a bioactive glycoside of Rehmannia glutinosa, a traditional Chinese
herb frequently prescribed for treating chemotherapy-induced pancytopenia. Despite its …

Defects in translation lead to changes in the expression of proteins that can serve as drivers
of cancer formation. Here, we show that cytosolic NAD+ synthesis plays an essential role in …

miRNAs constitute a class of non-coding RNA that act as powerful epigenetic regulators in
animal and plant cells. In order to identify putative tumor-suppressor miRNAs we profiled the …

Simple Summary Ribosome biosynthesis has emerged as an excellent target for inhibition of
cancer cell growth and proliferation. We used a high throughput screen to identify potent …

c-Myc promotes cell growth by enhancing ribosomal biogenesis and translation.
Deregulated expression of c-Myc and aberrant ribosomal biogenesis and translation …

The neddylation inhibitor MLN4924/Pevonedistat is in clinical trials for multiple cancers.
Efficacy is generally attributed to cullin RING ligase (CRL) inhibition, but the contribution of …

Orellana et al.(2021) and Dai et al.(2021) demonstrate that increased m 7 G modification of
a subset of tRNAs by the METTL1/WDR4 complex stabilizes these mRNAs against decay …

Background Targeting ribosome biogenesis to activate p53 has recently emerged as a
therapeutic strategy in human cancer. Among various ribosomal proteins, RPL11 centralizes …

Accumulating evidences suggest that the composition and functional roles of ribosomes are
heterogeneous in cells, partly due to the temporal-spatial expression of paralogous …