Many neurodegenerative disorders, including Parkinson's, Alzheimer's, and amyotrophic
lateral sclerosis, are well known to involve the accumulation of disease-specific proteins …

This article reviews current knowledge of neurofilament structure, phosphorylation, and
function and neurofilament involvement in disease. Neurofilaments are obligate …

Neurofilaments (NFs) are the major intermediate filaments in most mature neurons. Genetic
approaches have now proven that NFs are an essential determinant for radial growth of …

Five major types of intermediate filament (IF) proteins are expressed in mature neurons: the
three neurofilament proteins (NF‐L, NF‐M, and NF‐H), α‐internexin, and peripherin. While …

Neurofilament protein alterations are found in many neurodegenerative diseases, such as
amyotrophic lateral sclerosis, Parkinson, Alzheimer, and Charcot-Marie-Tooth. Abnormal …

Neurofilaments (NFs) are unique among tissue-specific classes of intermediate filaments
(IFs) in being heteropolymers composed of four subunits (NF-L [neurofilament light]; NF-M …

Neurofilaments (NF) are the most abundant cytoskeletal component of large myelinated
axons from adult central and peripheral nervous system. Here, we provide an overview of …

Neurofilaments are uniquely complex among classes of intermediate filaments in being
composed of four subunits (NFL, NFM, NFH and alpha-internexin in the CNS) that differ in …

Intermediate filaments represent the most abundant cytoskeletal element in mature neurons.
Mutations and/or accumulations of neuronal intermediate filament proteins are frequently …

Neurofilaments (NFs) are the most abundant structural components in large-diameter
myelinated axons. Assembled as obligate heteropolymers requiring NF-L and …