Neurobehavioral dysfunction in non-alcoholic steatohepatitis is associated with hyperammonemia, gut dysbiosis, and metabolic and functional brain regional deficits

SG Higarza, S Arboleya, M Gueimonde… - PLoS …, 2019 - journals.plos.org
Non-alcoholic steatohepatitis (NASH) is one of the most prevalent diseases worldwide.
While it has been suggested to cause nervous impairment, its neurophysiological basis …

Cognitive functions, neurotransmitter alterations, and hippocampal microstructural changes in mice caused by feeding on western diet

RJP Custodio, Z Hobloss, M Myllys, R Hassan… - Cells, 2023 - mdpi.com
Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD) is the most common
chronic liver disease in Western countries. It is becoming increasingly evident that …

Modulation of hippocampal TLR4/BDNF signal pathway using probiotics is a step closer towards treating cognitive impairment in NASH model

SK Mohammed, YM Magdy, DAA El-Waseef… - Physiology & …, 2020 - Elsevier
Abstarct Background and Aim: Disturbance of gut microbiota plays a role in induction and
progression of non alcoholic steatohepatitis (NASH) and the associated cognitive …

Gut dysbiosis and increased intestinal permeability drive microRNAs, NLRP-3 inflammasome and liver fibrosis in a nutritional model of non-alcoholic steatohepatitis in …

L Longo, J Tonin Ferrari, PH Rampelotto… - Clinical and …, 2020 - Taylor & Francis
Background/Aim The interactions between the gut and liver have been described in the
progression of non-alcoholic steatohepatitis (NASH). The aim of this study was to develop …

[HTML][HTML] Effect of chronic psychosocial stress on nonalcoholic steatohepatitis in mice

B Czech, ID Neumann, M Müller, SO Reber… - … journal of clinical and …, 2013 - ncbi.nlm.nih.gov
Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic lipid accumulation
which may progress towards inflammation (nonalcoholic steatohepatitis (NASH)). NAFLD is …

MAFLD progression contributes to altered thalamus metabolism and brain structure

S Nucera, S Ruga, A Cardamone, AR Coppoletta… - Scientific reports, 2022 - nature.com
Metabolic associated fatty liver disease (MAFLD), commonly known as non-alcoholic fatty
liver disease, represents a continuum of events characterized by excessive hepatic fat …

Cognitive dysfunction in non-alcoholic fatty liver disease—current knowledge, mechanisms and perspectives

K Kjærgaard, ACD Mikkelsen, CW Wernberg… - Journal of Clinical …, 2021 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) has emerged as the hepatic component of the
metabolic syndrome and now seemingly affects one-fourth of the world population. Features …

Modulation of serotonin in the gut-liver neural axis ameliorates the fatty and fibrotic changes in non-alcoholic fatty liver

M Ko, K Kamimura, T Owaki, T Nagoya… - Disease models & …, 2021 - journals.biologists.com
The etiology of non-alcoholic fatty liver disease (NAFLD) consists of various factors,
including neural signal pathways. However, the molecular mechanisms of the autonomic …

Depression and cognitive impairment—extrahepatic manifestations of NAFLD and NASH

M Colognesi, D Gabbia, S De Martin - Biomedicines, 2020 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) and its complication non-alcoholic steatohepatitis
(NASH) are important causes of liver disease worldwide. Recently, a significant association …

[HTML][HTML] Dynamic alterations in the gut microbiota and metabolome during the development of methionine-choline-deficient diet-induced nonalcoholic steatohepatitis

JZ Ye, YT Li, WR Wu, D Shi, DQ Fang… - World Journal of …, 2018 - ncbi.nlm.nih.gov
AIM To investigate changes in gut microbiota and metabolism during nonalcoholic
steatohepatitis (NASH) development in mice fed a methionine-choline-deficient (MCD) diet …