The immune system's ability to resist the invasion of foreign pathogens and the tolerance to
self-antigens are primarily centered on the efficient functions of the various subsets of T …

Even though the thymus is exquisitely sensitive to acute insults like infection, shock, or
common cancer therapies such as cytoreductive chemo-or radiation-therapy, it also has a …

T cell development is a complex and tightly regulated process involving reciprocal
interactions between the thymic stroma and differentiating thymocytes. Normal thymic …

The thymus constitutes the primary lymphoid organ for the generation of T cells. Its function
is particularly susceptible to various negative influences ranging from age-related involution …

As the primary site of T‐cell development, the thymus plays a key role in the generation of a
strong yet self‐tolerant adaptive immune response, essential in the face of the potential …

The thymus supports the development of T cells throughout life from hematopoietic
progenitor cells migrating from the bone marrow. During the early years after birth thymic …

Recent studies in mice and humans show that the importance of the thymus extends well
beyond the initial seeding of the peripheral T-cell pool. Although peripheral homeostasis …

The thymus is a primary lymphoid organ, essential for the development of T-cells that will
protect from invading pathogens, immune disorders, and cancer. The thymus decreases in …

The thymus is essential for T cell development and maturation. It is extremely sensitive to
atrophy, wherein loss in cellularity of the thymus and/or disruption of the thymic architecture …

The thymus plays a key role in adaptive immunity by generating a diverse population of T
cells that defend the body against pathogens. Various factors from disease and toxic insults …