Integrated spatially resolved metabolomics and network toxicology to investigate the hepatotoxicity mechanisms of component D of Polygonum multiflorum Thunb
HY Jiang, HY Gao, J Li, TY Zhou, ST Wang… - Journal of …, 2022 - Elsevier
Ethnopharmacological relevance The liver toxicity of Reynoutria multiflora (Thunb.)
Moldenke.(Polygonaceae)(Polygonum multiflorum Thunb, PM) has always attracted much …
Moldenke.(Polygonaceae)(Polygonum multiflorum Thunb, PM) has always attracted much …
A stepwise strategy integrating metabolomics and pseudotargeted spectrum–effect relationship to elucidate the potential hepatotoxic components in Polygonum …
Y Song, J Yang, X Hu, H Gao, P Wang… - Frontiers in …, 2022 - frontiersin.org
Polygonum multiflorum (PM) Thunb., a typical Chinese herbal medicine with different
therapeutic effect in raw and processed forms, has been used worldwide for thousands of …
therapeutic effect in raw and processed forms, has been used worldwide for thousands of …
Investigation of the idiosyncratic hepatotoxicity of Polygonum multiflorum Thunb. through metabolomics using GC-MS
Y Lin, R Xiao, B Xia, Z Zhang, C Li, P Wu… - … Medicine and Therapies, 2021 - Springer
Background The idiosyncratic hepatotoxicity of Polygonum multiflorum (PM) has attracted
considerable interest, but the idiosyncratically hepatotoxic components and endogenous …
considerable interest, but the idiosyncratically hepatotoxic components and endogenous …
UPLC/MS/MS-Based Metabolomics Study of the Hepatotoxicity and Nephrotoxicity in Rats Induced by Polygonum multiflorum Thunb.
Y Yan, N Shi, X Han, G Li, B Wen, J Gao - ACS omega, 2020 - ACS Publications
Polygonum multiflorum Thunb.(PM) is one of the most frequently used natural products in
China. Its hepatotoxicity has been proven and reported. However, chronic PM toxicity is a …
China. Its hepatotoxicity has been proven and reported. However, chronic PM toxicity is a …
Insights into the molecular mechanisms of Polygonum multiflorum Thunb-induced liver injury: a computational systems toxicology approach
An increasing number of cases of herb-induced liver injury (HILI) have been reported,
presenting new clinical challenges. In this study, taking Polygonum multiflorum Thunb (PmT) …
presenting new clinical challenges. In this study, taking Polygonum multiflorum Thunb (PmT) …
Metabolomic study on immunological stress-mediated hepatotoxicity of Polygonum multiflorum and its processed products of nine times steaming and nine times …
C LI, HE Qin, J TANG, M SHA, TU Can… - Acta Pharmaceutica …, 2017 - pesquisa.bvsalud.org
It is investigated that the hepatotoxicity of Polygonum multiflorum (PM) was attenuated by its
processed products of nine times steaming and nine times sunning (RPM) based on …
processed products of nine times steaming and nine times sunning (RPM) based on …
Metabolomic Study on Idiosyncratic Liver Injury Induced by Different Extracts of Polygonum multiflorum in Rats Integrated with Pattern Recognition and Enriched …
CY Li, C Tu, D Gao, RL Wang, HZ Zhang… - Frontiers in …, 2016 - frontiersin.org
Currently, numerous liver injury cases related to a famous Chinese herb-Polygonum
Multiflorum (Heshouwu in Chinese) have attracted great attention in many countries. Our …
Multiflorum (Heshouwu in Chinese) have attracted great attention in many countries. Our …
Exploration of components and mechanisms of Polygoni Multiflori Radix-induced hepatotoxicity using siRNA-mediated CYP3A4 or UGT1A1 knockdown liver cells
Y Hu, D Li, Z Quan, C Wang, M Zhou, Z Sun - Journal of …, 2021 - Elsevier
Abstract Ethnopharmacological relevance Polygoni Multiflori Radix, the dried root of
Polygonum multiflorum Thunb., and its processed products have been used as restoratives …
Polygonum multiflorum Thunb., and its processed products have been used as restoratives …
Hepatotoxicity and hepatoprotection of Polygonum multiflorum Thund. as two sides of the same biological coin
LY Ruan, MH Li, YX Xing, W Hong, C Chen… - Journal of …, 2019 - Elsevier
Abstract Ethnopharmacological relevance Polygonum multiflorum Thund., a well-known and
commonly-used TCM (Traditional Chinese Medicine) for treating hypertension …
commonly-used TCM (Traditional Chinese Medicine) for treating hypertension …
Urine metabolomics study on the liver injury in rats induced by raw and processed Polygonum multiflorum integrated with pattern recognition and pathways analysis
C Zhang, M Niu, Q Li, Y Zhao, Z Ma, Y Xiong… - Journal of …, 2016 - Elsevier
Ethnopharmacological relevance Polygonum multiflorum L. is a famous traditional Chinese
medicine that has always been perceived to be safe. Recently, the increasing case reports …
medicine that has always been perceived to be safe. Recently, the increasing case reports …
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