The microvasculature in the pancreatic islet is highly specialized for glucose sensing and
insulin secretion. Although pancreatic islet transplantation is a potentially life-changing …

Islet transplantation holds significant promise as a curative approach for type 1 diabetes
(T1D). However, the transition of islet transplantation from the experimental phase to …

The field of regenerative medicine offers the potential to significantly impact a wide spectrum
of healthcare issues, from diabetes to cardiovascular disease. In particular, the design of …

Islet transplantation is superior to extrinsic insulin supplementation in the treating severe
Type 1 diabetes. However, its efficiency and longevity are limited by substantial islet loss …

Islet transplantation is a promising therapy for treat-ment of type 1 diabetes. A real
breakthrough was reported when the Edmonton protocol was introduced in 2000. This …

The transplantation of pancreatic islets, following the Edmonton Protocol, is a promising
treatment for type I diabetics. However, the need for multiple donors to achieve insulin …

Islet transplantation for the purpose of treating insulin-sensitive diabetes is currently limited
by several factors, including islet survival posttransplantation. In the current study, a tissue …

Pancreatic-islet transplantation is a safe and noninvasive therapy for type 1 diabetes.
However, the currently applied site for transplantation, ie, the liver, is not the optimal site for …

Pancreatic islets are fragile cell clusters and many isolated islets are not suitable for
transplantation. Furthermore, following transplantation, islets will experience a state of …

Despite the clinical success of intrahepatic islet transplantation in treating type 1 diabetes,
factors specific to this transplantation site hinder long-term insulin independence. The …