In this era of unprecedented longevity, healthy aging is an important public health priority.
Avoiding or shortening the period of disability or dementia before death is critical to …

Both physical and cognitive deficits occur in the aging process. We operationally defined the
phenomenon as physio-cognitive decline syndrome (PCDS) and aimed to decipher its …

Advancing age is the focus of recent studies on familial and sporadic Alzheimer's disease
(AD), suggesting a prolonged pre-clinical phase several decades before the onset of …

The frailty syndrome has recently attracted attention of the scientific community and public
health organizations as precursor and contributor of age-related conditions (particularly …

Objectives To explore associations between PCDS, incident dementia and mortality risk and
evaluate the potential of its reversibility. Methods 963 participants from the I-Lan …

In the widely accepted «cycle of frailty» concept, individuals can enter the cycle through any
of its five components (inactivity, weight loss, weakness, slowness, and exhaustion), leading …

Since the concept and operational definition of “cognitive frailty”(simultaneous presence of
physical frailty and cognitive impairment without concurrent dementia) were proposed by the …

Accepted for publication July 30, 2013 cognitive frailty, there are many examples of people
who are vulnerable to subsequent functional decline based on the existence of subtle …

While the clinical hallmark of Alzheimer's disease (AD) is progressive loss of memory and
other cognitive abilities, there is increasing recognition that persons with AD also exhibit …

Introduction Cognitive frailty (CF) is associated with dementia and disability. It was initially
proposed in 2013 by the International Institute of Nutrition and Aging and the International …