Over the past three decades, numerous reports have addressed several aspects of drug
resistance phenomena. However, little is known regarding the impact that dietary …

Folate was identified as an essential micronutrient early in the twentieth century and anti-
folate chemotherapy such as 5-fluorouracil (5-FU) has been central to the medical …

Folates are essential nutrients for the cell for DNA synthesis. From a nutritional perspective,
a high folate status may have a beneficial/protective effect against cancer, birth defects and …

Background Capecitabine is an oral chemotherapeutic drug showing antitumor activity
through inhibition of thymidylate synthase, an enzyme involved in folate metabolism. There …

Folate metabolism is a target for various chemotherapeutic drugs. Folate and its synthetic
variant folic acid are B-vitamins. To what extent these vitamins impact treatment tolerance in …

Folic acid (FA) fortification and widespread supplemental use have significantly increased
folate status in North America. Furthermore,> 50% of colorectal cancer patients use FA …

Throughout the history of cancer chemotherapy, the control of drug-related toxicity has been
a major concern. Antifolates such as methotrexate also have a reputation for sporadic and …

Folate homeostasis and antiproliferative activity of folates and antifolates. - Abstract - Europe
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Abstract Background 5-Fluorouracil (5-FU) chemotherapy is associated with severe and
unpredictable toxicity in a significant proportion of patients. 5, 10-Methylenetetrahydrofolate …

Folate metabolism is the target of two major drug groups: folate antagonists (for example,
methotrexate) and thymidylate synthase inhibitors (for example, 5-fluorouracil). These …