Lantibiotics are believed to have a conceivable potential to be used as therapeutics,
especially against clinically resistant bacterial strains. However, their low solubility and poor …

Nisin is the prototype of the lantibiotic group of antimicrobial peptides. It exhibits broad
spectrum inhibition of Gram‐positive bacteria including important food pathogens and …

The emergence and dissemination of antibiotic resistant bacteria is a major medical
challenge. Lantibiotics are highly modified bacterially produced antimicrobial peptides that …

Nisin A is the most thoroughly investigated member of the lantibiotic family of antimicrobial
peptides. In addition to a long history of safe use as a food antimicrobial, its activity against …

The lantibiotics are a class of bacterially produced antimicrobial peptides (bacteriocins) that
contain several unusual amino acids resulting from enzyme-mediated post-translational …

Nisin, a typical lantibiotic, has robust antimicrobial activity combined with limited cytotoxicity,
and the development of resistance to it is slow. These properties make nisin a promising …

Nisin A is the best known and most extensively characterized lantibiotic. As it is ribosomally
synthesized, bioengineering‐based strategies can be used to generate variants. We have …

The antimicrobial peptide nisin contains the uncommon amino acid residues lanthionine
and methyl‐lanthionine, which are post‐translationally formed from Ser, Thr and Cys …

Nisin is a naturally occurring bioactive small peptide produced by Lactococcus lactis subsp.
lactis and belongs to the Type A (I) lantibiotics. Due to its potent antimicrobial activity, it has …

Herein, we describe a scalable purification of the lantibiotic nisin via an
extraction/precipitation approach using a biphasic system, which can be carried out up to 40 …