Peripheral vascular remodeling during ischemia

S Lin, R Lin, H Zhang, Q Xu, Y He - Frontiers in Pharmacology, 2022 - frontiersin.org
About 230 million people worldwide suffer from peripheral arterial disease (PAD), and the
prevalence is increasing year by year. Multiple risk factors, including smoking, dyslipidemia …

New directions in therapeutic angiogenesis and arteriogenesis in peripheral arterial disease

BH Annex, JP Cooke - Circulation research, 2021 - Am Heart Assoc
The prevalence of peripheral arterial disease (PAD) in the United States exceeds 10 million
people, and PAD is a significant cause of morbidity and mortality across the globe. PAD is …

Current medical therapy and revascularization in peripheral artery disease of the lower limbs: impacts on subclinical chronic inflammation

AL Cecchini, F Biscetti, M Manzato, L Lo Sasso… - International Journal of …, 2023 - mdpi.com
Peripheral artery disease (PAD), coronary artery disease (CAD), and cerebrovascular
disease (CeVD) are characterized by atherosclerosis and inflammation as their underlying …

Endothelial cell dysfunction: Implications for the pathogenesis of peripheral artery disease

MM Kavurma, C Bursill, CP Stanley… - Frontiers in …, 2022 - frontiersin.org
Peripheral artery disease (PAD) is caused by occluded or narrowed arteries that reduce
blood flow to the lower limbs. The treatment focuses on lifestyle changes, management of …

Therapeutic angiogenesis for peripheral artery disease: lessons learned in translational science

SR Iyer, BH Annex - Basic to translational science, 2017 - jacc.org
Peripheral arterial disease (PAD) is a major health care problem. There have been limited
advances in medical therapies, and a huge burden of symptomatic patients with intermittent …

[HTML][HTML] Epigenetic Regulation of Angiogenesis in Peripheral Artery Disease

NK Malhi, KW Southerland, L Lai… - Methodist DeBakey …, 2023 - ncbi.nlm.nih.gov
Peripheral arterial disease (PAD) represents a global health concern with a rising
prevalence attributed to factors such as obesity, diabetes, aging, and smoking. Among …

Diabetes impairs arteriogenesis in the peripheral circulation: review of molecular mechanisms

MS Ruiter, JM Van Golde, NC Schaper… - Clinical …, 2010 - portlandpress.com
Patients suffering from both diabetes and PAD (peripheral arterial disease) are at risk of
developing critical limb ischaemia and ulceration, and potentially requiring limb amputation …

Role of angiogenic transdifferentiation in vascular recovery

JP Cooke, L Lai - Frontiers in Cardiovascular Medicine, 2023 - frontiersin.org
Tissue repair requires the orchestration of multiple processes involving a multiplicity of
cellular effectors, signaling pathways, and cell-cell communication. The regeneration of the …

Donepezil can improve ischemic muscle atrophy by activating angiomyogenic properties of satellite cells

T Noguchi, Y Kakinuma, M Arikawa, K Okazaki… - Circulation …, 2014 - jstage.jst.go.jp
Background: Saving more limbs of patients with peripheral arterial disease (PAD) from
amputation by accelerating angiogenesis in affected limbs has been anticipated for years …

Stromal Cell–Derived Factor-1–Mediated Angiogenesis for Peripheral Arterial Disease: Ready for Prime Time?

NG Frangogiannis - Circulation, 2011 - Am Heart Assoc
Atherosclerotic peripheral arterial disease (PAD) is a major cause of morbidity in Western
societies and significantly reduces quality of life in affected individuals. 1 The prevalence of …