Neutrophil metabolomics in severe COVID-19 reveal GAPDH as a suppressor of neutrophil extracellular trap formation

Y Li, JS Hook, Q Ding, X Xiao, SS Chung… - Nature …, 2023 - nature.com
Severe COVID-19 is characterized by an increase in the number and changes in the
function of innate immune cells including neutrophils. However, it is not known how the …

Metabolic reprograming shapes neutrophil functions in severe COVID‐19

R Borella, S De Biasi, A Paolini… - European Journal of …, 2022 - Wiley Online Library
To better understand the mechanisms at the basis of neutrophil functions during SARS‐CoV‐
2, we studied patients with severe COVID‐19 pneumonia. They had high blood proportion of …

Neutrophil extracellular traps contribute to COVID-19 hyperinflammation and humoral autoimmunity

J Torres-Ruiz, A Absalón-Aguilar, M Nuñez-Aguirre… - Cells, 2021 - mdpi.com
The coronavirus disease 2019 (COVID-19) is related to enhanced production of NETs, and
autoimmune/autoinflammatory phenomena. We evaluated the proportion of low-density …

Neutrophil extracellular traps (NETs) and damage‐associated molecular patterns (DAMPs): two potential targets for COVID‐19 treatment

S Cicco, G Cicco, V Racanelli… - Mediators of …, 2020 - Wiley Online Library
COVID‐19 is a pandemic disease caused by the new coronavirus SARS‐CoV‐2 that mostly
affects the respiratory system. The consequent inflammation is not able to clear viruses. The …

SARS-CoV-2 infection paralyzes cytotoxic and metabolic functions of the immune cells

Y Singh, C Trautwein, R Fendel, N Krickeberg… - Heliyon, 2021 - cell.com
The SARS-CoV-2 virus is the causative agent of the global COVID-19 infectious disease
outbreak, which can lead to acute respiratory distress syndrome (ARDS). However, it is still …

[HTML][HTML] Neutrophil extracellular traps in COVID-19

Y Zuo, S Yalavarthi, H Shi, K Gockman, M Zuo… - JCI insight, 2020 - ncbi.nlm.nih.gov
In severe cases of coronavirus disease 2019 (COVID-19), viral pneumonia progresses to
respiratory failure. Neutrophil extracellular traps (NETs) are extracellular webs of chromatin …

A multi-omics longitudinal study reveals alteration of the leukocyte activation pathway in COVID-19 patients

K Suvarna, A Salkar, V Palanivel… - Journal of Proteome …, 2021 - ACS Publications
Severe coronavirus disease 2019 (COVID-19) infection may lead to lung injury, multi-organ
failure, and eventually death. Cytokine storm due to excess cytokine production has been …

[HTML][HTML] Metabolic modeling of single bronchoalveolar macrophages reveals regulators of hyperinflammation in COVID-19

Q Zhao, Z Yu, S Zhang, XR Shen, H Yang, Y Xu, Y Liu… - Iscience, 2022 - cell.com
SARS-CoV-2 infection induces imbalanced immune response such as hyperinflammation in
patients with severe COVID-19. Here, we studied the immunometabolic regulatory …

Neutrophils in COVID-19: recent insights and advances

J Li, K Zhang, ye Zhang, Z Gu, C Huang - Virology journal, 2023 - Springer
Abstract Coronavirus disease 2019 (COVID-19) is an acute respiratory disease caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which can lead to acute …

SARS-CoV-2–triggered neutrophil extracellular traps mediate COVID-19 pathology

FP Veras, MC Pontelli, CM Silva… - Journal of Experimental …, 2020 - rupress.org
Severe COVID-19 patients develop acute respiratory distress syndrome that may progress to
cytokine storm syndrome, organ dysfunction, and death. Considering that neutrophil …