Unilateral ischemia reperfusion injury (UIRI) with longer ischemia time is associated with an
increased risk of acute renal injury and chronic kidney disease. Exosomes can transport …

The kidney injury induced by ischemia-reperfusion (IR) usually comes with irreversible renal
fibrosis, a process that develops into chronic kidney disease (CKD), but the underlying …

Tubular epithelial cells (TECs) represent the primary site of renal ischemia/reperfusion injury
(RIRI). However, whether the damage of TECs could drive the initiation of inflammation was …

Tubule injury is a characteristic pathological feature of acute kidney injury (AKI) and
determines the prognosis of kidney disease. However, the exact mechanism of tubule injury …

Tubulointerstitial inflammation is a common characteristic of acute and chronic kidney injury.
However, the mechanism by which the initial injury of tubular epithelial cells (TECs) drives …

Exosomes have been shown to effectively regulate the biological functions of target cells.
Here, we investigated the protective effect and mechanism of hypoxia-induced renal tubular …

Rationale: With the widespread development of the interventional technique for
cardiovascular diseases and the widespread use of contrast medium (CM), the incidence of …

Hypoxia promotes tubulointerstitial inflammation in the kidney. Although hypoxia inducible
factor-1α (HIF-1α) is a master regulator of the response to hypoxia, the exact mechanisms …

Rationale: Ureteral obstruction-induced hydronephrosis is associated with renal fibrosis and
progressive chronic kidney disease (CKD). Exosome-mediated cell-cell communication has …

Renal ischemia/reperfusion (I/R) injury is the main reason for acute kidney injury (AKI) and is
closely related to high morbidity and mortality. In this study, we found that exosomes from …