Target‐Specific Bioorthogonal Reactions for Precise Biomedical Applications
Bioorthogonal chemistry is a promising toolbox for dissecting biological processes in the
native environment. Recently, bioorthogonal reactions have attracted considerable attention …
native environment. Recently, bioorthogonal reactions have attracted considerable attention …
Bioorthogonal catalysis for biomedical applications
Bioorthogonal chemistry, referring to chemical reactions occurring in a physiological
environment without interfering with native biochemical reactions, has witnessed substantial …
environment without interfering with native biochemical reactions, has witnessed substantial …
Development and application of bond cleavage reactions in bioorthogonal chemistry
J Li, PR Chen - Nature Chemical Biology, 2016 - nature.com
Bioorthogonal chemical reactions are a thriving area of chemical research in recent years as
an unprecedented technique to dissect native biological processes through chemistry …
an unprecedented technique to dissect native biological processes through chemistry …
Developing bioorthogonal probes to span a spectrum of reactivities
SS Nguyen, JA Prescher - Nature Reviews Chemistry, 2020 - nature.com
Bioorthogonal chemistries enable researchers to interrogate biomolecules in living systems.
These reactions are highly selective and biocompatible, and can be performed in many …
These reactions are highly selective and biocompatible, and can be performed in many …
In vivo applications of bioorthogonal reactions: chemistry and targeting mechanisms
MMA Mitry, F Greco, HMI Osborn - Chemistry–A European …, 2023 - Wiley Online Library
Bioorthogonal chemistry involves selective biocompatible reactions between functional
groups that are not normally present in biology. It has been used to probe biomolecules in …
groups that are not normally present in biology. It has been used to probe biomolecules in …
Finding the right (bioorthogonal) chemistry
DM Patterson, LA Nazarova, JA Prescher - ACS chemical biology, 2014 - ACS Publications
Bioorthogonal chemistries can be used to tag diverse classes of biomolecules in cells and
other complex environments. With over 20 unique transformations now available, though …
other complex environments. With over 20 unique transformations now available, though …
The future of bioorthogonal chemistry
NK Devaraj - ACS central science, 2018 - ACS Publications
Bioorthogonal reactions have found widespread use in applications ranging from glycan
engineering to in vivo imaging. Researchers have devised numerous reactions that can be …
engineering to in vivo imaging. Researchers have devised numerous reactions that can be …
Bioorthogonal chemistry: fishing for selectivity in a sea of functionality
EM Sletten, CR Bertozzi - Angewandte Chemie International …, 2009 - Wiley Online Library
The study of biomolecules in their native environments is a challenging task because of the
vast complexity of cellular systems. Technologies developed in the last few years for the …
vast complexity of cellular systems. Technologies developed in the last few years for the …
A decade of bioorthogonal chemistry
CR Bertozzi - Accounts of chemical research, 2011 - ACS Publications
Inventing new chemical reactions is a long-standing passion of chemists, as reflected in the
ever-popular field of reaction methodology. Historically, the environment in which newly …
ever-popular field of reaction methodology. Historically, the environment in which newly …
[HTML][HTML] Recent developments in bioorthogonal chemistry and the orthogonality within
MLWJ Smeenk, J Agramunt, KM Bonger - Current Opinion in Chemical …, 2021 - Elsevier
The emergence of bioorthogonal reactions has greatly advanced research in the fields of
biology and medicine. They are not only valuable for labeling, tracking, and understanding …
biology and medicine. They are not only valuable for labeling, tracking, and understanding …