Many lines of evidence have indicated the therapeutic potential of rescuing mitochondrial
integrity by targeting specific mitochondrial quality control pathways in neurodegenerative …

In recent years, several important advances have been made in our understanding of the
pathways that lead to cell dysfunction and death in Parkinson's disease (PD) and …

The mitochondrion is a unique organelle with a diverse range of functions. Mitochondrial
dysfunction is a key pathological process in several neurodegenerative diseases …

Maintaining the functional integrity of mitochondria is pivotal for cellular survival. It appears
that neuronal homeostasis depends on high-fidelity mitochondria, in particular …

Neurodegenerative diseases, including Alzheimer's, Parkinson's, Huntington's, and
amyotrophic lateral sclerosis, are characterized by a progressive loss of selective neuron …

The human brain is a highly complex organ with remarkable energy demands. Although it
represents only 2% of the total body weight, it accounts for 20% of all oxygen consumption …

Tuned mitochondrial physiology is fundamental for qualitative cellular function. This is
particularly relevant for neurons, whose pathology is frequently associated with …

Mitochondria are essential for neuronal survival and mitochondrial dysfunction is a hallmark
of neurodegeneration. The loss in mitochondrial energy production, oxidative stress, and …

The human brain has high energetic expenses and consumes over 20% of total oxygen
metabolism. Abnormal brain energy homeostasis leads to various brain diseases. Among …

Mitochondria are critical for homeostasis and metabolism in all cellular eukaryotes. Brain
mitochondria are the primary source of fuel that supports many brain functions, including …