The spectrum of tumours arising in childhood is fundamentally different from that seen in
adults, and they are known to be divergent from adult malignancies in terms of cellular …

Four out of five children diagnosed with cancer can be cured with contemporary cancer
therapy. This represents a dramatic improvement since 50 years ago when the cure rate of …

Importance Pediatric cancers represent a unique case with respect to cancer genomics and
precision medicine, as the mutation frequency is low, and targeted therapies are less …

Abstract iTHER is a Dutch prospective national precision oncology program aiming to define
tumour molecular profiles in children and adolescents with primary very high-risk, relapsed …

The use of targeted small-molecule therapeutics and immunotherapeutics has been limited
to date in pediatric oncology. Recently, the number of pediatric approvals has risen, and …

Improvements in protocol-driven clinical trials and supportive care for children and
adolescents with cancer have reduced mortality rates by more than 50% over the past three …

Seven years after the launch of the European Paediatric Medicine Regulation, limited
progress in paediatric oncology drug development remains a major concern amongst …

Cancer is a leading cause of death in both adults and children, but in terms of absolute
numbers, pediatric cancer is a relatively rare disease. The rarity of pediatric cancer is …

Abstract The 'Individualized Therapy for Relapsed Malignancies in Childhood'(INFORM)
precision medicine study is a nationwide German program for children with high-risk …

Cancer is the leading disease-related cause of death in children in developed countries.
Arising in the context of actively growing tissues, childhood cancers are fundamentally …