Ischemic stroke is a leading cause of death worldwide, mainly in western countries. So far,
approved therapies rely on reperfusion of the affected brain area, by intravenous …

Stroke is a leading disease for morbidity and the second leading cause of mortality following
ischemic heart disease. The health burden for stroke ranks the fourth of all diseases as …

For over 40 years, attempts to develop treatments that protect neurons and other brain cells
against the cellular and biochemical consequences of cerebral ischaemia in acute …

Translation from basic science bench research in ischemic stroke to bedside treatment of
patients suffering ischemic stroke remains a difficult challenge. Despite literally hundreds of …

On average, every 4 min an individual dies from a stroke, accounting for one out of every 18
deaths in the United States. Approximately 795,000 Americans have a new or recurrent …

The high morbidity and mortality rate of ischemic stroke in humans has led to the
development of numerous animal models that replicate human stroke to further understand …

Ischemic stroke is a leading cause of death and disability. However, very few
neuroprotective agents have shown promise for treatment of ischemic stroke in clinical trials …

Despite the impressive efficacies demonstrated in preclinical research, hundreds of
potentially neuroprotective drugs have failed to provide effective neuroprotection for …

Achieving neuroprotection in ischemic stroke patients has been a multidecade medical
challenge. Numerous clinical trials were discontinued in futility and many were terminated in …

Investigators acknowledge the limitations of rodent or non-human primate stroke models,
hundreds of putative neuroprotectants have been evaluated in preclinical models, but not …